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Role of Host Genes in Influenza Virus Replication


Shaw, Megan L; Stertz, S (2017). Role of Host Genes in Influenza Virus Replication. In: Shaw, Megan L; Stertz, S. Current Topics in Microbiology and Immunology. Berlin, Heidelberg: Springer, 1-39.

Abstract

At every step of their replication cycle influenza viruses depend heavily on their host cells. The multifaceted interactions that occur between the virus and its host cell determine the outcome of the infection, including efficiency of progeny virus production, tropism, and pathogenicity. In order to understand viral disease and develop therapies for influenza it is therefore pertinent to study the intricate interplay between influenza viruses and their required host factors. Here, we review the current knowledge on host cell factors required by influenza virus at the different stages of the viral replication cycle. We also discuss the roles of host factors in zoonotic transmission of influenza viruses and their potential for developing novel antivirals.

Abstract

At every step of their replication cycle influenza viruses depend heavily on their host cells. The multifaceted interactions that occur between the virus and its host cell determine the outcome of the infection, including efficiency of progeny virus production, tropism, and pathogenicity. In order to understand viral disease and develop therapies for influenza it is therefore pertinent to study the intricate interplay between influenza viruses and their required host factors. Here, we review the current knowledge on host cell factors required by influenza virus at the different stages of the viral replication cycle. We also discuss the roles of host factors in zoonotic transmission of influenza viruses and their potential for developing novel antivirals.

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Additional indexing

Item Type:Book Section, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Medical Virology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:23 June 2017
Deposited On:10 Oct 2017 13:14
Last Modified:10 Oct 2017 13:19
Publisher:Springer
Publisher DOI:https://doi.org/10.1007/82_2017_30
Related URLs:http://www.recherche-portal.ch/ZAD:default_scope:ebi01_prod010062532 (Library Catalogue)
PubMed ID:28643205

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