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Points to consider when doing a trial primarily involving the heart


Allanore, Yannick; Distler, Oliver; Walker, Ulrich A; Khanna, Dinesh; Furst, Daniel E; Meune, Christophe (2017). Points to consider when doing a trial primarily involving the heart. Rheumatology, 56(Suppl 5):v12-v16.

Abstract

Cardiac involvement contributes to the severity of SSc and should carefully be investigated and managed in SSc patients. Although it is commonly sub-clinical, once symptomatic it has a poor prognosis. Several complementary tools (circulating biomarkers, electrocardiography, echocardiography, scintigraphy or MRI) allow the assessment of all the various cardiac structures (endocardium, myocardium and pericardium) and heart function. Treatment remains empirical but cardiac trials in SSc can add data to the treatment of this complication.

Abstract

Cardiac involvement contributes to the severity of SSc and should carefully be investigated and managed in SSc patients. Although it is commonly sub-clinical, once symptomatic it has a poor prognosis. Several complementary tools (circulating biomarkers, electrocardiography, echocardiography, scintigraphy or MRI) allow the assessment of all the various cardiac structures (endocardium, myocardium and pericardium) and heart function. Treatment remains empirical but cardiac trials in SSc can add data to the treatment of this complication.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:arrhythmia, cardiac fibrosis, heart, heart failure, myocarditis, pericarditis, systemic sclerosis
Date:1 September 2017
Deposited On:24 Oct 2017 14:05
Last Modified:19 Feb 2018 09:00
Publisher:Oxford University Press
ISSN:1462-0324
OA Status:Closed
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/rheumatology/kex198
PubMed ID:28992169

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Language: English
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