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Heritability of hair cortisol and genetic overlap with psychological variables


Abstract

Background: Measuring cortisol in hair is a promising method to assess alterations of the biological stress-response which is altered in psychiatric disorders. While first studies indicate a contribution of genetic factors to inter-individual variance in hair cortisol concentration (HCC), it is unknown whether genes influencing HCC also account for inter-individual differences in psychological variables. The existence of such a true biological link would point at a causal involvement of the HPA axis in the vulnerability for psychiatric disorders.

Abstract

Background: Measuring cortisol in hair is a promising method to assess alterations of the biological stress-response which is altered in psychiatric disorders. While first studies indicate a contribution of genetic factors to inter-individual variance in hair cortisol concentration (HCC), it is unknown whether genes influencing HCC also account for inter-individual differences in psychological variables. The existence of such a true biological link would point at a causal involvement of the HPA axis in the vulnerability for psychiatric disorders.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Legal Medicine
Dewey Decimal Classification:340 Law
610 Medicine & health
Language:English
Date:2017
Deposited On:02 Nov 2017 14:28
Last Modified:19 Feb 2018 09:07
Publisher:Elsevier
ISSN:0306-4530
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.psyneuen.2017.07.452

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