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Comparison of allografts and xenografts used for alveolar ridge preservation. A clinical and histomorphometric RCT in humans


Serrano Méndez, Carlos Alberto; Lang, Niklaus Peter; Caneva, Martina; Ramírez Lemus, Gloria; Mora Solano, Gerardo; Botticelli, Daniele (2017). Comparison of allografts and xenografts used for alveolar ridge preservation. A clinical and histomorphometric RCT in humans. Clinical Implant Dentistry and Related Research, 19(4):608-615.

Abstract

BACKGROUND: Several types of bone grafts are used in ridge preservation procedures.
PURPOSE: To compare the healing of allografts and xenografts applied for alveolar ridge preservation.
MATERIALS AND METHODS: Twenty volunteers in need of extraction of a single-rooted tooth prior to implant installation were randomized into two groups. One group received a deproteinized cancellous bovine bone xenograft embedded in a 10% collagen matrix and the other a demineralized freeze-dried cortical bone allograft. A collagen membrane was used to cover the grafts, flaps were sutured. At baseline and 6 months later, clinical measurements including vertical and horizontal bone dimensions were taken. Histomorphometric analysis was performed.
RESULTS: Both groups showed shrinkage of bone dimensions. At mesial, center and distal sites, the vertical changes in dimension were -0.6, 0.5, and -0.1 mm for the allograft and -1.1, -0.4, and -0.9 mm for the xenograft. The horizontal changes in dimensions were -1.4 mm for the allograft and -2.6 mm for the xenograft. New bone and residual graft material were 25.5 ± 10.1% and 33.8 ± 9.4% at the allograft and 35.3 ± 16.8% and 22.2 ± 13.4% at the xenograft sites. None of the differences was statistically significant.
CONCLUSION: Both grafting materials are suitable for the preservation of the alveolar ridge.

Abstract

BACKGROUND: Several types of bone grafts are used in ridge preservation procedures.
PURPOSE: To compare the healing of allografts and xenografts applied for alveolar ridge preservation.
MATERIALS AND METHODS: Twenty volunteers in need of extraction of a single-rooted tooth prior to implant installation were randomized into two groups. One group received a deproteinized cancellous bovine bone xenograft embedded in a 10% collagen matrix and the other a demineralized freeze-dried cortical bone allograft. A collagen membrane was used to cover the grafts, flaps were sutured. At baseline and 6 months later, clinical measurements including vertical and horizontal bone dimensions were taken. Histomorphometric analysis was performed.
RESULTS: Both groups showed shrinkage of bone dimensions. At mesial, center and distal sites, the vertical changes in dimension were -0.6, 0.5, and -0.1 mm for the allograft and -1.1, -0.4, and -0.9 mm for the xenograft. The horizontal changes in dimensions were -1.4 mm for the allograft and -2.6 mm for the xenograft. New bone and residual graft material were 25.5 ± 10.1% and 33.8 ± 9.4% at the allograft and 35.3 ± 16.8% and 22.2 ± 13.4% at the xenograft sites. None of the differences was statistically significant.
CONCLUSION: Both grafting materials are suitable for the preservation of the alveolar ridge.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Dental Medicine > Clinic for Fixed and Removable Prosthodontics
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:allograft, alveolar ridge reconstruction, bone grafting, tooth extraction, xenograft
Language:English
Date:August 2017
Deposited On:30 Nov 2017 16:28
Last Modified:19 Feb 2018 09:27
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:1523-0899
OA Status:Closed
Publisher DOI:https://doi.org/10.1111/cid.12490
PubMed ID:28466494

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