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G-CSF-induced remission in two cases of acute myeloid leukemia


Benz, R; Goede, J S; Parlier, V; Mühlematter, D; Jotterand, M; Fehr, J (2008). G-CSF-induced remission in two cases of acute myeloid leukemia. Leukemia Research, 32 (7):1148-1152.

Abstract

We report on two elderly patients with newly diagnosed acute myeloid leukemia (AML) who were treated in palliative intention because of comorbidities and intermediate or poor risk cytogenetics. Both received G-CSF to reduce the risk of infection related to neutropenia. Interestingly, one patient achieved a full hematological remission and the other a peripheral remission with dramatic reduction of the bone marrow blast count. Although a direct therapeutic effect of myeloid growth factors seems to be unusual in AML, the use of G-CSF or GM-CSF may be recommended in patients such as elderly patients who are not suited for intensive chemotherapy.

Abstract

We report on two elderly patients with newly diagnosed acute myeloid leukemia (AML) who were treated in palliative intention because of comorbidities and intermediate or poor risk cytogenetics. Both received G-CSF to reduce the risk of infection related to neutropenia. Interestingly, one patient achieved a full hematological remission and the other a peripheral remission with dramatic reduction of the bone marrow blast count. Although a direct therapeutic effect of myeloid growth factors seems to be unusual in AML, the use of G-CSF or GM-CSF may be recommended in patients such as elderly patients who are not suited for intensive chemotherapy.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Hematology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:July 2008
Deposited On:17 Feb 2009 08:19
Last Modified:05 Apr 2016 13:02
Publisher:Elsevier
ISSN:0145-2126
Additional Information:Full text at http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T98-4RGG2NW-1-3&_cdi=5108&_user=5294990&_orig=search&_coverDate=07%2F31%2F2008&_sk=999679992&view=c&wchp=dGLzVzz-zSkzV&md5=11c3519bd7a318be3f74769b36d04afa&ie=/sdarticle.pdf
Publisher DOI:https://doi.org/10.1016/j.leukres.2007.11.020
PubMed ID:18166225

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