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Pharmacological modulation of cell death in organ transplantation


Cippà, Pietro E; Fehr, Thomas (2017). Pharmacological modulation of cell death in organ transplantation. Transplant International, 30(9):851-859.

Abstract

New options to pharmacologically modulate fundamental mechanisms of regulated cell death are rapidly evolving and found first clinical applications in cancer therapy. Here, we present an overview on how the recent advances in the understanding of the biology and pharmacology of cell death might influence research and clinical practice in solid organ transplantation. Of particular interest are the novel opportunities related to organ preservation and immunomodulation, which might contribute to promote organ repair and to develop more selective ways to modulate allogeneic immune responses to prevent rejection and induce immunological tolerance.

Abstract

New options to pharmacologically modulate fundamental mechanisms of regulated cell death are rapidly evolving and found first clinical applications in cancer therapy. Here, we present an overview on how the recent advances in the understanding of the biology and pharmacology of cell death might influence research and clinical practice in solid organ transplantation. Of particular interest are the novel opportunities related to organ preservation and immunomodulation, which might contribute to promote organ repair and to develop more selective ways to modulate allogeneic immune responses to prevent rejection and induce immunological tolerance.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Nephrology
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:apoptosis; cell death; immunomodulation; transplantation
Language:English
Date:2017
Deposited On:06 Dec 2017 15:24
Last Modified:06 Dec 2017 15:24
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0934-0874
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1111/tri.12977
PubMed ID:28480540

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