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Moderate sugar-sweetened beverage consumption impairs low density lipoprotein metabolism in healthy young men: a randomized, controlled, double-blinded study


Liechti, Marc. Moderate sugar-sweetened beverage consumption impairs low density lipoprotein metabolism in healthy young men: a randomized, controlled, double-blinded study. 2017, University of Zurich, Faculty of Medicine.

Abstract

Background:
Sugar-sweetened beverage consumption in high quantities impairs lipid metabo-lism and therefore causes metabolic disorders in obese subjects. However, the effect of sugar sweetened beverages in lower doses on normal weight healthy subjects remains less clear.

Objective:
The aim of the study was to investigate the impact of sugar-sweetened beverage consumption over 7 weeks on low density lipoprotein particle size and distribution.

Design:
96 normal weight, healthy young male subjects were included in a randomized, double blind, monocentric, controlled nutritional trial and were randomly assigned to 4 intervention groups. Over a period of 7 weeks, subjects were instructed to consume on a daily basis 600ml of sugar-sweetened beverages containing either 80g fructose, 80g glucose or 80g sucrose, whereas a control group was advised to abstain completely from sugar-sweetened beverages.

Results:
Small low density lipoprotein particles (22-25.6nm diameter) increased and large low density lipoprotein particles (25.6-28.5nm diameter) decreased after sugar-sweetened beverage consumption compared with baseline (p = 0.04). The sucrose containing intervention decreased the largest low density lipoprotein particles (27.2-28.5nm diameter) significantly (p = 0.039).

Conclusion:
This study shows that even moderate consumption of sugar-sweetened beverag-es leads to adverse effects on low density lipoprotein metabolism in normal weight, healthy young men.

Abstract

Background:
Sugar-sweetened beverage consumption in high quantities impairs lipid metabo-lism and therefore causes metabolic disorders in obese subjects. However, the effect of sugar sweetened beverages in lower doses on normal weight healthy subjects remains less clear.

Objective:
The aim of the study was to investigate the impact of sugar-sweetened beverage consumption over 7 weeks on low density lipoprotein particle size and distribution.

Design:
96 normal weight, healthy young male subjects were included in a randomized, double blind, monocentric, controlled nutritional trial and were randomly assigned to 4 intervention groups. Over a period of 7 weeks, subjects were instructed to consume on a daily basis 600ml of sugar-sweetened beverages containing either 80g fructose, 80g glucose or 80g sucrose, whereas a control group was advised to abstain completely from sugar-sweetened beverages.

Results:
Small low density lipoprotein particles (22-25.6nm diameter) increased and large low density lipoprotein particles (25.6-28.5nm diameter) decreased after sugar-sweetened beverage consumption compared with baseline (p = 0.04). The sucrose containing intervention decreased the largest low density lipoprotein particles (27.2-28.5nm diameter) significantly (p = 0.039).

Conclusion:
This study shows that even moderate consumption of sugar-sweetened beverag-es leads to adverse effects on low density lipoprotein metabolism in normal weight, healthy young men.

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Additional indexing

Item Type:Master's Thesis
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Endocrinology and Diabetology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2017
Deposited On:12 Dec 2017 16:17
Last Modified:12 Dec 2017 16:17
Number of Pages:23

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