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Ein kleiner Einstieg zu Diagnostik und Prädiktion des Lungenkarzinoms


Soltermann, Alex (2017). Ein kleiner Einstieg zu Diagnostik und Prädiktion des Lungenkarzinoms. Therapeutische Umschau. Revue thérapeutique, 74(4):157-164.

Abstract

Lung cancer is still one of the most frequent tumours and associated with high mortality, due to the fact that the patients are frequently diagnosed in the advanced stages 3 or 4. Non-small cell lung carcinoma (NSLCL) consists of the histologic variants adenocarcinoma, squamous cell carcinoma, and large cell carcinoma and is separated from small cell lung carcinoma (SCLC). NSCLC is primarily resected and SCLC is mainly treated with radio-chemotherapy. Predictive oncogenic markers such as mutations in the EGFR gene are established only for adenocarcinoma, whereas immunotherapy may be performed in all entities. For personalized patient therapy, it is imminent that comprehensive staging data, including molecular pathologic findings, are discussed on a tumour board. Complete molecular pathologic work-up requires sufficient amount of tumour tissue.

Abstract

Lung cancer is still one of the most frequent tumours and associated with high mortality, due to the fact that the patients are frequently diagnosed in the advanced stages 3 or 4. Non-small cell lung carcinoma (NSLCL) consists of the histologic variants adenocarcinoma, squamous cell carcinoma, and large cell carcinoma and is separated from small cell lung carcinoma (SCLC). NSCLC is primarily resected and SCLC is mainly treated with radio-chemotherapy. Predictive oncogenic markers such as mutations in the EGFR gene are established only for adenocarcinoma, whereas immunotherapy may be performed in all entities. For personalized patient therapy, it is imminent that comprehensive staging data, including molecular pathologic findings, are discussed on a tumour board. Complete molecular pathologic work-up requires sufficient amount of tumour tissue.

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Additional indexing

Other titles:A brief introduction to the diagnostics and prediction of bronchial carcinoma
Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
Dewey Decimal Classification:610 Medicine & health
Language:German
Date:September 2017
Deposited On:08 Dec 2017 16:35
Last Modified:19 Feb 2018 09:33
Publisher:Hogrefe Verlag
ISSN:0040-5930
OA Status:Closed
Publisher DOI:https://doi.org/10.1024/0040-5930/a000899
PubMed ID:28950769

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