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The European Collaborative Project on inflammation and vascular wall remodeling in Atherosclerosis - Intravascular Ultrasound (ATHEROREMO-IVUS) study


de Boer, Sanneke P M; Baran, Yael; Garcia-Garcia, Hector M; Eskin, Itamar; Lenzen, Mattie; Kleber, Marcus E; Regar, Evelyn; de Jaegere, Peter J; Ligthart, Jurgen M; van Geuns, Robert Jan; Lehtimäki, Tehro; Laaksonen, Reijo; Boersma, Eric; März, Winfried; Halperin, Erin; Serruys, Patrick W; Koenig, Wolfgang (2017). The European Collaborative Project on inflammation and vascular wall remodeling in Atherosclerosis - Intravascular Ultrasound (ATHEROREMO-IVUS) study. EuroIntervention:Epub ahead of print.

Abstract

AIMS: The European Collaborative Project on Inflammation and Vascular Wall Remodelling in Atherosclerosis - Intravascular Ultrasound (ATHEROREMO-IVUS) study has been designed as an exploratory clinical study to investigate the associations between genetic variation, coronary atherosclerosis phenotypes, and plaque vulnerability as determined by IVUS.
METHODS AND RESULTS: The ATHEROREMO-IVUS study is a prospective, observational study of 581 patients with stable angina pectoris or acute coronary syndrome (ACS) who were referred for coronary angiography to the Thoraxcenter, Rotterdam, enriched with 265 IBIS-2 participants (total population, n=846). Prior to catheterization, blood samples were drawn for genetic analyses. During the catheterization procedure, IVUS was performed in a nonculprit coronary artery. The primary endpoint was the presence of vulnerable plaque as determined by IVUS virtual histology (VH). In addition, we performed a genome wide association study of plaque morphology. We observed strong signals associated with plaque morphology in several chromosomal regions: twelve SNPs (rs17300022, rs6904106, rs17177818, rs2248165, rs2477539, rs16865681, rs2396058, rs4753663, rs4082252, rs6932, rs12862206, rs6780676) in or near eight different genes (GNA12, NMBR, SFMBT2, CUL3, SESN3, SLC22A25, EFBN2, SEC62) were most significant.
CONCLUSIONS: In conclusion, we found twelve SNPS in or in the proximity of eight genes, which were possibly associated with markers of vulnerable plaque.

Abstract

AIMS: The European Collaborative Project on Inflammation and Vascular Wall Remodelling in Atherosclerosis - Intravascular Ultrasound (ATHEROREMO-IVUS) study has been designed as an exploratory clinical study to investigate the associations between genetic variation, coronary atherosclerosis phenotypes, and plaque vulnerability as determined by IVUS.
METHODS AND RESULTS: The ATHEROREMO-IVUS study is a prospective, observational study of 581 patients with stable angina pectoris or acute coronary syndrome (ACS) who were referred for coronary angiography to the Thoraxcenter, Rotterdam, enriched with 265 IBIS-2 participants (total population, n=846). Prior to catheterization, blood samples were drawn for genetic analyses. During the catheterization procedure, IVUS was performed in a nonculprit coronary artery. The primary endpoint was the presence of vulnerable plaque as determined by IVUS virtual histology (VH). In addition, we performed a genome wide association study of plaque morphology. We observed strong signals associated with plaque morphology in several chromosomal regions: twelve SNPs (rs17300022, rs6904106, rs17177818, rs2248165, rs2477539, rs16865681, rs2396058, rs4753663, rs4082252, rs6932, rs12862206, rs6780676) in or near eight different genes (GNA12, NMBR, SFMBT2, CUL3, SESN3, SLC22A25, EFBN2, SEC62) were most significant.
CONCLUSIONS: In conclusion, we found twelve SNPS in or in the proximity of eight genes, which were possibly associated with markers of vulnerable plaque.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiovascular Surgery
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:26 September 2017
Deposited On:19 Dec 2017 15:47
Last Modified:19 Dec 2017 15:47
Publisher:Europa Digital and Publishing
ISSN:1774-024X
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.4244/EIJ-D-17-00180
PubMed ID:28943493

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