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Inhaled Drugs and Systemic Corticosteroids for Bronchopulmonary Dysplasia


Bassler, Dirk; van den Anker, John (2017). Inhaled Drugs and Systemic Corticosteroids for Bronchopulmonary Dysplasia. Pediatric Clinics of North America, 64(6):1355-1367.

Abstract

All definitions of bronchopulmonary dysplasia (BPD) have limitations and a new definition for the purpose of clinical research, benchmarking, and prognostic prediction is needed. Different inhaled and systemic drugs are currently used to prevent or treat BPD. Despite some positive effects on BPD, more information about the effects of inhaled corticosteroids is required to assess overall efficacy and associated risks. One needs to balance the risks of neurodevelopmental impairment owing to systemic corticosteroids against those of BPD itself. Future studies should, therefore, focus on infants with a very high risk of developing BPD and include pharmacokinetics and long-term developmental outcomes.

Abstract

All definitions of bronchopulmonary dysplasia (BPD) have limitations and a new definition for the purpose of clinical research, benchmarking, and prognostic prediction is needed. Different inhaled and systemic drugs are currently used to prevent or treat BPD. Despite some positive effects on BPD, more information about the effects of inhaled corticosteroids is required to assess overall efficacy and associated risks. One needs to balance the risks of neurodevelopmental impairment owing to systemic corticosteroids against those of BPD itself. Future studies should, therefore, focus on infants with a very high risk of developing BPD and include pharmacokinetics and long-term developmental outcomes.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neonatology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:December 2017
Deposited On:27 Dec 2017 08:48
Last Modified:19 Feb 2018 09:43
Publisher:Elsevier
ISSN:0031-3955
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.pcl.2017.08.012
PubMed ID:29173790

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