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Shock 2017 military supplement an overview of two human trials of perfluorocarbon emulsions in non-cardiac surgery


Spahn, Donat R; Keipert, Peter E (2017). Shock 2017 military supplement an overview of two human trials of perfluorocarbon emulsions in non-cardiac surgery. Shock:Epub ahead of print.

Abstract

Perfluorochemicals (PFCs) constitute one class of artificial oxygen carriers that are being produced completely synthetically. One formulation that has been evaluated extensively in clinical trials is a 60% w/v perflubron-based emulsion. Efficacy and safety of this perflubron emulsion was evaluated in a Phase 2 and a large prospective randomized Phase 3 multicenter European study, which collectively included a total of 639 patients. Perflubron emulsion was highly successful in improving organ function, reversing physiologic transfusion triggers and in reducing the need for allogeneic blood transfusions. There were no major safety issues.

Abstract

Perfluorochemicals (PFCs) constitute one class of artificial oxygen carriers that are being produced completely synthetically. One formulation that has been evaluated extensively in clinical trials is a 60% w/v perflubron-based emulsion. Efficacy and safety of this perflubron emulsion was evaluated in a Phase 2 and a large prospective randomized Phase 3 multicenter European study, which collectively included a total of 639 patients. Perflubron emulsion was highly successful in improving organ function, reversing physiologic transfusion triggers and in reducing the need for allogeneic blood transfusions. There were no major safety issues.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Anesthesiology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2017
Deposited On:28 Dec 2017 16:59
Last Modified:19 Feb 2018 09:51
Publisher:Lippincott Williams & Wilkins
ISSN:1073-2322
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1097/SHK.0000000000000986
PubMed ID:28930917

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