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Tim-3, Lag-3, and TIGIT


Joller, Nicole; Kuchroo, Vijay K (2017). Tim-3, Lag-3, and TIGIT. In: Yoshimura, Akihiko. Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity. Cham: Springer, 127-156.

Abstract

Co-inhibitory receptors play a key role in regulating T cell responses and maintaining immune homeostasis. Their inhibitory function prevents autoimmune responses but also restricts the ability of T cells to mount effective immune responses against tumors or persistent pathogens. T cells express a module of co-inhibitory receptors, which display great diversity in expression, structure, and function. Here, we focus on the co-inhibitory receptors Tim-3, Lag-3, and TIGIT and how they regulate T cell function, maintenance of self-tolerance, their role in regulating ongoing T cell responses at peripheral tissues, and their synergistic effects in regulating autoimmunity and antitumor responses.

Abstract

Co-inhibitory receptors play a key role in regulating T cell responses and maintaining immune homeostasis. Their inhibitory function prevents autoimmune responses but also restricts the ability of T cells to mount effective immune responses against tumors or persistent pathogens. T cells express a module of co-inhibitory receptors, which display great diversity in expression, structure, and function. Here, we focus on the co-inhibitory receptors Tim-3, Lag-3, and TIGIT and how they regulate T cell function, maintenance of self-tolerance, their role in regulating ongoing T cell responses at peripheral tissues, and their synergistic effects in regulating autoimmunity and antitumor responses.

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Additional indexing

Item Type:Book Section, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Experimental Immunology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2017
Deposited On:09 Jan 2018 15:36
Last Modified:30 Mar 2018 06:41
Publisher:Springer
Series Name:Current topics in microbiology and immunology
ISSN:0070-217X
ISBN:978-3-319-68928-9
OA Status:Closed
Publisher DOI:https://doi.org/10.1007/82_2017_62
PubMed ID:28900677
Project Information:
  • : FunderH2020
  • : Grant ID677200
  • : Project TitleImmune Regulation - How Infection History Shapes the Immune System: Pathogen-induced Changes in Regulatory T Cells

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