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Novel mechanisms in immune tolerance to allergens during natural allergen exposure and allergen-specific immunotherapy


van de Veen, Willem; Wirz, Oliver F; Globinska, Anna; Akdis, Mübeccel (2017). Novel mechanisms in immune tolerance to allergens during natural allergen exposure and allergen-specific immunotherapy. Current Opinion in Immunology, 48:74-81.

Abstract

Allergen-specific immunotherapy (AIT) has been used for more than 100 years as a clinical tolerance-inducing and immune tolerance-inducing therapy for allergic diseases and represents a potentially curative method of treatment. AIT functions through multiple mechanisms including early desensitization of basophils and mast cells, regulating T-cell and B-cell responses, changing antibody isotypes, and decreasing activation, mediator release and affected tissue migration of eosinophils, basophils, and mast cells. Similar molecular and cellular mechanisms have been observed in subcutaneous AIT, sublingual AIT and peptide immunotherapy as well as natural tolerance to high doses of allergen exposure in beekeepers and cat owners.

Abstract

Allergen-specific immunotherapy (AIT) has been used for more than 100 years as a clinical tolerance-inducing and immune tolerance-inducing therapy for allergic diseases and represents a potentially curative method of treatment. AIT functions through multiple mechanisms including early desensitization of basophils and mast cells, regulating T-cell and B-cell responses, changing antibody isotypes, and decreasing activation, mediator release and affected tissue migration of eosinophils, basophils, and mast cells. Similar molecular and cellular mechanisms have been observed in subcutaneous AIT, sublingual AIT and peptide immunotherapy as well as natural tolerance to high doses of allergen exposure in beekeepers and cat owners.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Swiss Institute of Allergy and Asthma Research
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:October 2017
Deposited On:26 Jan 2018 10:12
Last Modified:19 Feb 2018 10:33
Publisher:Elsevier
ISSN:0952-7915
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.coi.2017.08.012
PubMed ID:28888176

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