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Microbeam radiation therapy - grid therapy and beyond: a clinical perspective


Schültke, Elisabeth; Balosso, Jacques; Breslin, Thomas; Cavaletti, Guido; Djonov, Valentin; Esteve, Francois; Grotzer, Michael; Hildebrandt, Guido; Valdman, Alexander; Laissue, Jean (2017). Microbeam radiation therapy - grid therapy and beyond: a clinical perspective. British Journal of Radiology, 90(1078):20170073.

Abstract

Microbeam irradiation is spatially fractionated radiation on a micrometer scale. Microbeam irradiation with therapeutic intent has become known as microbeam radiation therapy (MRT). The basic concept of MRT was developed in the 1980s, but it has not yet been tested in any human clinical trial, even though there is now a large number of animal studies demonstrating its marked therapeutic potential with an exceptional normal tissue sparing effect. Furthermore, MRT is conceptually similar to macroscopic grid based radiation therapy which has been used in clinical practice for decades. In this review, the potential clinical applications of MRT are analysed for both malignant and non-malignant diseases.

Abstract

Microbeam irradiation is spatially fractionated radiation on a micrometer scale. Microbeam irradiation with therapeutic intent has become known as microbeam radiation therapy (MRT). The basic concept of MRT was developed in the 1980s, but it has not yet been tested in any human clinical trial, even though there is now a large number of animal studies demonstrating its marked therapeutic potential with an exceptional normal tissue sparing effect. Furthermore, MRT is conceptually similar to macroscopic grid based radiation therapy which has been used in clinical practice for decades. In this review, the potential clinical applications of MRT are analysed for both malignant and non-malignant diseases.

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Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:October 2017
Deposited On:30 Jan 2018 11:16
Last Modified:01 Apr 2018 01:20
Publisher:British Institute of Radiology
ISSN:0007-1285
OA Status:Hybrid
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1259/bjr.20170073
PubMed ID:28749174

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