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Anterior cingulate volume predicts response to psychotherapy and functional connectivity with the inferior parietal cortex in major depressive disorder


Sambataro, Fabio; Doerig, Nadja; Hänggi, Jürgen; Wolf, Robert Christian; Brakowski, Janis; Grosse Holtforth, Martin; Seifritz, Erich; Spinelli, Simona (2018). Anterior cingulate volume predicts response to psychotherapy and functional connectivity with the inferior parietal cortex in major depressive disorder. European Neuropsychopharmacology, 28(1):138-148.

Abstract

In major depressive disorder (MDD), the anterior cingulate cortex (ACC) has been associated with clinical outcome as well as with antidepressant treatment response. Nonetheless, the association between individual differences in ACC structure and function and the response to cognitive behavioral therapy (CBT) is still unexplored. For this aim, twenty-five unmedicated patients with MDD were scanned with structural and resting state functional magnetic resonance imaging before the beginning of CBT treatment. ACC morphometry was correlated with clinical changes following psychotherapy. Furthermore, whole-brain resting state functional connectivity with the ACC was correlated with clinical measures. Greater volume in the left subgenual (subACC), the right pregenual (preACC), and the bilateral supragenual (supACC) predicted depressive symptoms improvement after CBT. Greater subACC volume was related to stronger functional connectivity with the inferior parietal cortex and dorsolateral prefrontal cortex. Stronger subACC-inferior parietal cortex connectivity correlated with greater adaptive rumination. Greater preACC volume was associated with stronger functional connectivity with the inferior parietal cortex and ventrolateral prefrontal cortex. In contrast, greater right supACC volume was related to lower functional connectivity with the inferior parietal cortex. These results suggest that ACC volume and its functional connectivity with the fronto-parietal cortex are associated with CBT response in MDD, and this may be mediated by adaptive forms of rumination. Our findings support the role of the subACC as a potential predictor for CBT response.

Abstract

In major depressive disorder (MDD), the anterior cingulate cortex (ACC) has been associated with clinical outcome as well as with antidepressant treatment response. Nonetheless, the association between individual differences in ACC structure and function and the response to cognitive behavioral therapy (CBT) is still unexplored. For this aim, twenty-five unmedicated patients with MDD were scanned with structural and resting state functional magnetic resonance imaging before the beginning of CBT treatment. ACC morphometry was correlated with clinical changes following psychotherapy. Furthermore, whole-brain resting state functional connectivity with the ACC was correlated with clinical measures. Greater volume in the left subgenual (subACC), the right pregenual (preACC), and the bilateral supragenual (supACC) predicted depressive symptoms improvement after CBT. Greater subACC volume was related to stronger functional connectivity with the inferior parietal cortex and dorsolateral prefrontal cortex. Stronger subACC-inferior parietal cortex connectivity correlated with greater adaptive rumination. Greater preACC volume was associated with stronger functional connectivity with the inferior parietal cortex and ventrolateral prefrontal cortex. In contrast, greater right supACC volume was related to lower functional connectivity with the inferior parietal cortex. These results suggest that ACC volume and its functional connectivity with the fronto-parietal cortex are associated with CBT response in MDD, and this may be mediated by adaptive forms of rumination. Our findings support the role of the subACC as a potential predictor for CBT response.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:06 Faculty of Arts > Institute of Psychology
Dewey Decimal Classification:150 Psychology
Language:English
Date:January 2018
Deposited On:08 Feb 2018 15:17
Last Modified:31 Jul 2018 04:31
Publisher:Elsevier
ISSN:0924-977X
Additional Information:Supplementary data associated with this article can be found in the online version at doi:10.1016/j.euroneuro.2017.11.008
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.euroneuro.2017.11.008
PubMed ID:29239789
Project Information:
  • : FunderForschungskredit of the University of Zurich
  • : Grant ID
  • : Project Title
  • : FunderKurt und Senta Herrmann Foundation
  • : Grant ID
  • : Project Title
  • : Project Websitehttp://www.researchers.uzh.ch/static/fnf/stiftungen/stiftung.php?id=175
  • : FunderSNSF
  • : Grant IDPZ00P3_126363
  • : Project TitleHuman and mouse-model study of serotonin transporter involvement in abnormal negative feedback processing in depression: translational neural imaging and neuropsychological testing.
  • : FunderSNSF
  • : Grant IDPZ00P3_146001
  • : Project TitleHuman and mouse-model study of serotonin transporter involvement in abnormal negative feedback processing in depression: translational neural imaging and neuropsychological testing.
  • : FunderSNSF
  • : Grant IDPP00P1_123377
  • : Project TitleExplicit and implicit change of depression in exposure-based cognitive therapy
  • : FunderFoundation for Research in Science and the Humanities at the University of Zurich
  • : Grant ID
  • : Project Title

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