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Eukaryotic ribosome assembly, transport and quality control


Peña, Cohue; Hurt, Ed; Panse, Vikram Govind (2017). Eukaryotic ribosome assembly, transport and quality control. Nature Structural & Molecular Biology, 24(9):689-699.

Abstract

Eukaryotic ribosome synthesis is a complex, energy-consuming process that takes place across the nucleolus, nucleoplasm and cytoplasm and requires more than 200 conserved assembly factors. Here, we discuss mechanisms by which the ribosome assembly and nucleocytoplasmic transport machineries collaborate to produce functional ribosomes. We also highlight recent cryo-EM studies that provided unprecedented snapshots of ribosomes during assembly and quality control.

Abstract

Eukaryotic ribosome synthesis is a complex, energy-consuming process that takes place across the nucleolus, nucleoplasm and cytoplasm and requires more than 200 conserved assembly factors. Here, we discuss mechanisms by which the ribosome assembly and nucleocytoplasmic transport machineries collaborate to produce functional ribosomes. We also highlight recent cryo-EM studies that provided unprecedented snapshots of ribosomes during assembly and quality control.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Medical Microbiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:7 September 2017
Deposited On:27 Feb 2018 17:05
Last Modified:14 Mar 2018 17:58
Publisher:Nature Publishing Group
ISSN:1545-9985
OA Status:Closed
Publisher DOI:https://doi.org/10.1038/nsmb.3454
PubMed ID:28880863

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