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Bilateral neurotoxic lesions in NCM before tutoring onset do not prevent successful tutor song learning


Canopoli, Alessandro; Zai, Anja; Hahnloser, Richard (2017). Bilateral neurotoxic lesions in NCM before tutoring onset do not prevent successful tutor song learning. Matters:12.5/20.

Abstract

Sensorimotor learning crucially depends on the ability to acquire a sensory memory for shaping motor commands. Such learning is conveniently studied in young songbirds when they memorize the song of an adult singer and gradually transform their own vocalizations toward the memorized target song. Here we study the involvement of the Caudal Medial Nidopallium (NCM), a higher auditory cortical area, in acquisition of a song memory. NCM has previously been shown to be involved in tutor song memorization. To study the necessity of NCM in this process, we perform large irreversible NCM lesions using ibotenic acid injections in about 40-days old juvenile zebra finches, before their first exposure to tutor song. Surprisingly, NCM-lesioned juveniles successfully copied the tutor song at least as well as untreated control animals, showing that a fully intact NCM is not required for tutor song memory formation and normal song development.

Abstract

Sensorimotor learning crucially depends on the ability to acquire a sensory memory for shaping motor commands. Such learning is conveniently studied in young songbirds when they memorize the song of an adult singer and gradually transform their own vocalizations toward the memorized target song. Here we study the involvement of the Caudal Medial Nidopallium (NCM), a higher auditory cortical area, in acquisition of a song memory. NCM has previously been shown to be involved in tutor song memorization. To study the necessity of NCM in this process, we perform large irreversible NCM lesions using ibotenic acid injections in about 40-days old juvenile zebra finches, before their first exposure to tutor song. Surprisingly, NCM-lesioned juveniles successfully copied the tutor song at least as well as untreated control animals, showing that a fully intact NCM is not required for tutor song memory formation and normal song development.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Neuroinformatics
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:2017
Deposited On:01 Mar 2018 11:16
Last Modified:14 Mar 2018 18:00
Publisher:ScienceMatters AG
ISSN:2297-8240
OA Status:Hybrid
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.19185/matters.201612000007
Official URL:https://dx.doi.org/10.19185/matters.201612000007

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