Header

UZH-Logo

Maintenance Infos

A biological blueprint for the axons of superficial layer pyramidal cells in cat primary visual cortex


Martin, Kevan A C; Roth, Stephan; Rusch, Elisha S (2017). A biological blueprint for the axons of superficial layer pyramidal cells in cat primary visual cortex. Brain Structure & Function, 222(8):3407-3430.

Abstract

Pyramidal cells in the superficial layers of neocortex of higher mammals form a lateral network of axon clusters known as the ‘daisy’ network. The role of these axon clusters remains speculative and we still lack a comprehensive quantitative description of the single neurons forming the daisy or their heterogeneity. We filled intracellularly 50 superficial layer pyramidal neurons in the cat primary visual cortex and reconstructed the axonal tree and their synaptic boutons in 3D. Individual bouton clusters were identified using an objective mean-shift algorithm. By parameterizing the morphology of these 50 axonal trees and the 217 bouton clusters they formed, we were able to extract one set of relatively constant parameters and another set of variable parameters. Both sets combined allowed us to outline a comprehensive biological blueprint of superficial layer pyramidal neurons. Overall, our detailed analysis supports the hypothesis that pyramidal neurons use their lateral clusters to combine differential contextual cues, required for context-dependent processing of natural scenes.

Abstract

Pyramidal cells in the superficial layers of neocortex of higher mammals form a lateral network of axon clusters known as the ‘daisy’ network. The role of these axon clusters remains speculative and we still lack a comprehensive quantitative description of the single neurons forming the daisy or their heterogeneity. We filled intracellularly 50 superficial layer pyramidal neurons in the cat primary visual cortex and reconstructed the axonal tree and their synaptic boutons in 3D. Individual bouton clusters were identified using an objective mean-shift algorithm. By parameterizing the morphology of these 50 axonal trees and the 217 bouton clusters they formed, we were able to extract one set of relatively constant parameters and another set of variable parameters. Both sets combined allowed us to outline a comprehensive biological blueprint of superficial layer pyramidal neurons. Overall, our detailed analysis supports the hypothesis that pyramidal neurons use their lateral clusters to combine differential contextual cues, required for context-dependent processing of natural scenes.

Statistics

Citations

Dimensions.ai Metrics
2 citations in Web of Science®
2 citations in Scopus®
2 citations in Microsoft Academic
Google Scholar™

Altmetrics

Downloads

2 downloads since deposited on 01 Mar 2018
2 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Neuroinformatics
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:2017
Deposited On:01 Mar 2018 11:59
Last Modified:11 Jul 2018 14:21
Publisher:Springer
Number of Pages:1
ISSN:1863-2653
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1007/s00429-017-1410-6

Download

Download PDF  'A biological blueprint for the axons of superficial layer pyramidal cells in cat primary visual cortex'.
Preview
Content: Published Version
Filetype: PDF
Size: 9MB
View at publisher
Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)