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Bilateral spontaneous regression of vestibular schwannoma in neurofibromatosis type 2: a case report


Sebök, M; van Niftrik, C H B; Bozinov, O (2018). Bilateral spontaneous regression of vestibular schwannoma in neurofibromatosis type 2: a case report. World Neurosurgery, 113:195-197.

Abstract

BACKGROUND Patients with neurofibromatosis type 2 and bilateral vestibular schwannoma (VS) are frequently treated surgically for any tumor progression, and often repeated surgery or radiation treatment is even considered. Some VS progression occurs without the development of new clinical symptoms, or it does not progress in size over many years, even in the absence of any specific treatment.
CASE DESCRIPTION We report now a 61-year-old male patient with neurofibromatosis type 2 presenting with bilateral VS. In a long-term follow-up, both had increased in size but also showed bilateral spontaneous regression during an 11-year follow-up period with a "watch and wait" strategy.
CONCLUSIONS We emphasize conservative treatment ("watch and wait") in older patients even with long-term tumor progression without significant compression related clinical symptoms.

Abstract

BACKGROUND Patients with neurofibromatosis type 2 and bilateral vestibular schwannoma (VS) are frequently treated surgically for any tumor progression, and often repeated surgery or radiation treatment is even considered. Some VS progression occurs without the development of new clinical symptoms, or it does not progress in size over many years, even in the absence of any specific treatment.
CASE DESCRIPTION We report now a 61-year-old male patient with neurofibromatosis type 2 presenting with bilateral VS. In a long-term follow-up, both had increased in size but also showed bilateral spontaneous regression during an 11-year follow-up period with a "watch and wait" strategy.
CONCLUSIONS We emphasize conservative treatment ("watch and wait") in older patients even with long-term tumor progression without significant compression related clinical symptoms.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurosurgery
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:conservative management, magnetic resonance imaging, neurofibromatosis type 2, spontaneous regression, tumor volume, vestibular schwannoma, “watch and wait”
Language:English
Date:21 February 2018
Deposited On:15 Mar 2018 13:52
Last Modified:19 Mar 2018 12:38
Publisher:Elsevier
ISSN:1878-8750
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.wneu.2018.02.075
PubMed ID:29477000

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Embargo till: 2019-03-01