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Significant association of slow vasogenic ICP waves with normal pressure hydrocephalus diagnosis


Spiegelberg, Andreas; Krause, Matthias; Meixensberger, Juergen; Seifert, Burkhardt; Kurtcuoglu, Vartan (2018). Significant association of slow vasogenic ICP waves with normal pressure hydrocephalus diagnosis. In: Heldt, Thomas. Intracranial Pressure & Neuromonitoring. Cham: Springer, 243-246.

Abstract

OBJECTIVE: We aimed to test whether there is an association of slow vasogenic wave (SVW) occurrence with positive response to external lumbar drainage (ELD) and ventriculoperitoneal shunting and to design a method for the recognition and quantification of SVWs in the intracranial pressure (ICP) signal.
MATERIALS AND METHODS: We constructed SVW templates using normalized sine waves. We calculated the cross-correlation between the respective SVW template and the ICP signal. This was followed by shifting the templates forward and performing the cross-correlation analysis again until the end of the recording. Cross-correlation values above a threshold were considered to be indicative of SVWs. This threshold was previously determined and validated on a sample of ICP records of six patients. We calculated the root mean square of the recognized SVW periods as a measure of signal strength. Time-averaged signal strength was calculated over the full recording time (ICP) and over the wave periods (ICP).
RESULTS: We determined ICPand ICPin recordings of 2 groups of patients presenting with Hakim's triad: 26 normal pressure hydrocephalus (NPH) patients and 20 non-NPH patients. We then tested whether there was an association between ICPor ICPand the respective diagnosis using a Mann-Whitney test. We found significant association between ICP(p = 0.014) and ICP(p = 0.022) and the diagnoses.
CONCLUSIONS: The described method based on pattern recognition in the time domain is suitable for the detection and quantification of SVWs in ICP signals. We found a significant association between the occurrence of SVWs and independent NPH diagnosis.

Abstract

OBJECTIVE: We aimed to test whether there is an association of slow vasogenic wave (SVW) occurrence with positive response to external lumbar drainage (ELD) and ventriculoperitoneal shunting and to design a method for the recognition and quantification of SVWs in the intracranial pressure (ICP) signal.
MATERIALS AND METHODS: We constructed SVW templates using normalized sine waves. We calculated the cross-correlation between the respective SVW template and the ICP signal. This was followed by shifting the templates forward and performing the cross-correlation analysis again until the end of the recording. Cross-correlation values above a threshold were considered to be indicative of SVWs. This threshold was previously determined and validated on a sample of ICP records of six patients. We calculated the root mean square of the recognized SVW periods as a measure of signal strength. Time-averaged signal strength was calculated over the full recording time (ICP) and over the wave periods (ICP).
RESULTS: We determined ICPand ICPin recordings of 2 groups of patients presenting with Hakim's triad: 26 normal pressure hydrocephalus (NPH) patients and 20 non-NPH patients. We then tested whether there was an association between ICPor ICPand the respective diagnosis using a Mann-Whitney test. We found significant association between ICP(p = 0.014) and ICP(p = 0.022) and the diagnoses.
CONCLUSIONS: The described method based on pattern recognition in the time domain is suitable for the detection and quantification of SVWs in ICP signals. We found a significant association between the occurrence of SVWs and independent NPH diagnosis.

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Additional indexing

Item Type:Book Section, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2018
Deposited On:19 Mar 2018 17:57
Last Modified:13 Apr 2018 11:41
Publisher:Springer
Number:126
ISSN:0065-1419
ISBN:978-3-319-65798-1
OA Status:Closed
Publisher DOI:https://doi.org/10.1007/978-3-319-65798-1_49
PubMed ID:29492569

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