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Shear-scaling-based approach for irreversible energy loss estimation in stenotic aortic flow – An in vitro study


Gülan, Utku; Binter, Christian; Kozerke, Sebastian; Holzner, Markus (2017). Shear-scaling-based approach for irreversible energy loss estimation in stenotic aortic flow – An in vitro study. Journal of Biomechanics, 56:89-96.

Abstract

Today, the functional and risk assessment of stenosed arteries is mostly based on ultrasound Doppler blood flow velocity measurements or catheter pressure measurements, which rely on several assumptions. Alternatively, blood velocity including turbulent kinetic energy (TKE) may be measured using MRI. The aim of the present study is to validate a TKE-based approach that relies on the fact that turbulence production is dominated by the flow’s shear to determine the total irreversible energy loss from MRI scans. Three-dimensional particle tracking velocimetry (3D-PTV) and phase-contrast magnetic resonance imaging (PC-MRI) simulations were performed in an anatomically accurate, compliant, silicon aortic phantom. We found that measuring only the laminar viscous losses does not reflect the true losses of stenotic flows since the contribution of the turbulent losses to the total loss become more dominant for more severe stenosis types (for example, the laminar loss is 0.0094 ± 0.0015 W and the turbulent loss is 0.0361 ± 0.0015 W for the Remax = 13,800 case, where Remax is the Reynolds number based on the velocity in the vena-contracta). We show that the commonly used simplified and modified Bernoulli’s approaches overestimate the total loss, while the new TKE-based method proposed here, referred to as “shear scaling” approach, results in a good agreement between 3D-PTV and simulated PC-MRI (mean error is around 10%). In addition, we validated the shear scaling approach on a geometry with post-stenotic dilatation using numerical data by Casas et al. (2016). The shear scaling-based method may hence be an interesting alternative for irreversible energy loss estimation to replace traditional approaches for clinical use. We expect that our results will evoke further research, in particular patient studies for clinical implementation of the new method.

Abstract

Today, the functional and risk assessment of stenosed arteries is mostly based on ultrasound Doppler blood flow velocity measurements or catheter pressure measurements, which rely on several assumptions. Alternatively, blood velocity including turbulent kinetic energy (TKE) may be measured using MRI. The aim of the present study is to validate a TKE-based approach that relies on the fact that turbulence production is dominated by the flow’s shear to determine the total irreversible energy loss from MRI scans. Three-dimensional particle tracking velocimetry (3D-PTV) and phase-contrast magnetic resonance imaging (PC-MRI) simulations were performed in an anatomically accurate, compliant, silicon aortic phantom. We found that measuring only the laminar viscous losses does not reflect the true losses of stenotic flows since the contribution of the turbulent losses to the total loss become more dominant for more severe stenosis types (for example, the laminar loss is 0.0094 ± 0.0015 W and the turbulent loss is 0.0361 ± 0.0015 W for the Remax = 13,800 case, where Remax is the Reynolds number based on the velocity in the vena-contracta). We show that the commonly used simplified and modified Bernoulli’s approaches overestimate the total loss, while the new TKE-based method proposed here, referred to as “shear scaling” approach, results in a good agreement between 3D-PTV and simulated PC-MRI (mean error is around 10%). In addition, we validated the shear scaling approach on a geometry with post-stenotic dilatation using numerical data by Casas et al. (2016). The shear scaling-based method may hence be an interesting alternative for irreversible energy loss estimation to replace traditional approaches for clinical use. We expect that our results will evoke further research, in particular patient studies for clinical implementation of the new method.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Uncontrolled Keywords:Biophysics, Rehabilitation, Orthopedics and Sports Medicine, Biomedical Engineering
Language:English
Date:2017
Deposited On:22 Mar 2018 11:46
Last Modified:19 Aug 2018 15:15
Publisher:Elsevier
ISSN:0021-9290
OA Status:Closed
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.jbiomech.2017.03.006
PubMed ID:28342532
Project Information:
  • : FunderSNSF
  • : Grant IDCR23I3_159686
  • : Project TitleNovel approach for image-based estimation of stenosis severity and energy loss in aortic flow
  • : FunderSNSF
  • : Grant IDCR23I3_144218
  • : Project TitleNon-Invasive Imaging of Energy Efficiency in the Cardiovascular System
  • : FunderSNSF
  • : Grant IDCR23I3_159686
  • : Project TitleNovel approach for image-based estimation of stenosis severity and energy loss in aortic flow
  • : FunderSNSF
  • : Grant IDCR23I3_144218
  • : Project TitleNon-Invasive Imaging of Energy Efficiency in the Cardiovascular System

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