Header

UZH-Logo

Maintenance Infos

Total Synthesis of Anachelin H


Gademann, Karl; Bethuel, Yann (2004). Total Synthesis of Anachelin H. Organic Letters, 6(25):4707-4710.

Abstract

The first total synthesis of anachelin H is reported. Starting from l-Ser, a stereodivergent synthesis of the polyketide fragment resulting in all possible diastereoisomers is described. The alkaloid peptide fragment is prepared via a tellurium-mediated oxidative aza annulation as the key step. Coupling of the fragments gave synthetic anachelin H, which was found to be identical to a sample of the natural product, thus confirming the configuration by total synthesis.

Abstract

The first total synthesis of anachelin H is reported. Starting from l-Ser, a stereodivergent synthesis of the polyketide fragment resulting in all possible diastereoisomers is described. The alkaloid peptide fragment is prepared via a tellurium-mediated oxidative aza annulation as the key step. Coupling of the fragments gave synthetic anachelin H, which was found to be identical to a sample of the natural product, thus confirming the configuration by total synthesis.

Statistics

Citations

Dimensions.ai Metrics
35 citations in Web of Science®
35 citations in Scopus®
19 citations in Microsoft Academic
Google Scholar™

Altmetrics

Downloads

1 download since deposited on 03 Apr 2018
1 download since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:2004
Deposited On:03 Apr 2018 15:06
Last Modified:13 Apr 2018 11:53
Publisher:American Chemical Society (ACS)
ISSN:1523-7052
OA Status:Closed
Publisher DOI:https://doi.org/10.1021/ol048068x

Download