Header

UZH-Logo

Maintenance Infos

Renal failure after high-dose methotrexate in a child homozygous for MTHFR C677T polymorphism


Turello, R; Rentsch, K; Di Paolo, E; Beck Popovic, M (2008). Renal failure after high-dose methotrexate in a child homozygous for MTHFR C677T polymorphism. Pediatric Blood & Cancer, 50(1):154-156.

Abstract

We report the case of an 11-year-old female treated for mediastinal T-cell lymphoma who presented renal failure following the second cycle of high-dose methotrexate (HDMTX). Because of life threatening plasma methotrexate (MTX) levels, carboxypeptidase G2 (CPDG2) was administered resulting in a dramatic decrease within 1 hr. The patient recovered from renal failure and no other side effects were observed. Homozygosity for the methylentetrahydrofolate reductase (MTHFR) C677T polymorphism diagnosed by molecular genetic analysis was the only explanation for this toxicity.

Abstract

We report the case of an 11-year-old female treated for mediastinal T-cell lymphoma who presented renal failure following the second cycle of high-dose methotrexate (HDMTX). Because of life threatening plasma methotrexate (MTX) levels, carboxypeptidase G2 (CPDG2) was administered resulting in a dramatic decrease within 1 hr. The patient recovered from renal failure and no other side effects were observed. Homozygosity for the methylentetrahydrofolate reductase (MTHFR) C677T polymorphism diagnosed by molecular genetic analysis was the only explanation for this toxicity.

Statistics

Citations

8 citations in Web of Science®
10 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

2 downloads since deposited on 25 Feb 2009
0 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Clinical Chemistry
Dewey Decimal Classification:610 Medicine & health
540 Chemistry
Language:English
Date:2008
Deposited On:25 Feb 2009 14:27
Last Modified:21 Nov 2017 14:01
Publisher:Wiley-Blackwell
ISSN:1545-5009
Additional Information:Wiley – Full text available online
Publisher DOI:https://doi.org/10.1002/pbc.21176
Official URL:http://www3.interscience.wiley.com/cgi-bin/fulltext/114200122/PDFSTART
PubMed ID:17387702

Download