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T-cell tolerance to inhaled allergens: mechanisms and therapeutic approaches


Akdis, M (2008). T-cell tolerance to inhaled allergens: mechanisms and therapeutic approaches. Expert Opinion on Biological Therapy, 8(6):769-777.

Abstract

BACKGROUND: Specific immune response to allergens is decisive in the development of clinically healthy or allergic states. OBJECTIVE: Recent developments in the mechanisms of allergen-specific peripheral tolerance can be used for future treatment modalities. METHODS: This review focuses on recent developments in allergen tolerance. RESULTS/CONCLUSION: The balance between allergen-specific IL-10-secreting T regulatory cells (Tr1) and T helper 2 (Th2) cells appears to be decisive in the development of allergic and healthy immune response against allergens. Induction of IL-10- and TGF-beta-producing Tr1 cells, IgG4-isotype-blocking antibodies, and suppressed mast cells, basophils and eosinophils represent major components of a relatively normalized immune response after allergen-specific immunotherapy and healthy immune response to aeroallergens in sensitized individuals.

Abstract

BACKGROUND: Specific immune response to allergens is decisive in the development of clinically healthy or allergic states. OBJECTIVE: Recent developments in the mechanisms of allergen-specific peripheral tolerance can be used for future treatment modalities. METHODS: This review focuses on recent developments in allergen tolerance. RESULTS/CONCLUSION: The balance between allergen-specific IL-10-secreting T regulatory cells (Tr1) and T helper 2 (Th2) cells appears to be decisive in the development of allergic and healthy immune response against allergens. Induction of IL-10- and TGF-beta-producing Tr1 cells, IgG4-isotype-blocking antibodies, and suppressed mast cells, basophils and eosinophils represent major components of a relatively normalized immune response after allergen-specific immunotherapy and healthy immune response to aeroallergens in sensitized individuals.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Swiss Institute of Allergy and Asthma Research
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2008
Deposited On:24 Feb 2009 11:41
Last Modified:05 Apr 2016 13:04
Publisher:Informa Healthcare
ISSN:1471-2598
Publisher DOI:https://doi.org/10.1517/14712598.8.6.769
PubMed ID:18476788

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