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Influence of ibuprofen-arginine on serum levels of nitric oxide metabolites in patients with chronic low back pain--a single-blind, placebo controlled pilot trial (ISRCTN18723747)


Sprott, H; Gay, R E; Michel, B A; Gay, S (2006). Influence of ibuprofen-arginine on serum levels of nitric oxide metabolites in patients with chronic low back pain--a single-blind, placebo controlled pilot trial (ISRCTN18723747). The Journal of Rheumatology, 33(12):2515-2518.

Abstract

OBJECTIVE: To determine whether ibuprofen-arginine has a cyclooxygenase-independent pain modulating property in addition to its known antiinflammatory effect. METHODS: Patients with chronic low back pain were randomly divided into 2 groups treated either with oral ibuprofen-arginine (400 mg) or with placebo. Blood was drawn from study subjects before, during, and after treatment and they were asked each time about the intensity of their pain. Concentrations of nitric oxide (NO) metabolites were determined. RESULTS: Twenty minutes after intake of ibuprofen-arginine, but not after placebo, there was a relevant and significant reduction of NO metabolites in serum. In both groups there was significant analgesic effect compared to baseline. CONCLUSION: An early lowering of the serum NO metabolite levels after ibuprofen-arginine administration could be detected in patients with chronic low back pain.

Abstract

OBJECTIVE: To determine whether ibuprofen-arginine has a cyclooxygenase-independent pain modulating property in addition to its known antiinflammatory effect. METHODS: Patients with chronic low back pain were randomly divided into 2 groups treated either with oral ibuprofen-arginine (400 mg) or with placebo. Blood was drawn from study subjects before, during, and after treatment and they were asked each time about the intensity of their pain. Concentrations of nitric oxide (NO) metabolites were determined. RESULTS: Twenty minutes after intake of ibuprofen-arginine, but not after placebo, there was a relevant and significant reduction of NO metabolites in serum. In both groups there was significant analgesic effect compared to baseline. CONCLUSION: An early lowering of the serum NO metabolite levels after ibuprofen-arginine administration could be detected in patients with chronic low back pain.

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Additional indexing

Item Type:Journal Article, not refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Integrative Human Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:December 2006
Deposited On:23 Mar 2009 16:16
Last Modified:05 Apr 2016 13:05
Publisher:Journal of Rheumatology Publishing
ISSN:0315-162X
Official URL:http://jrheum.org/content/33/12/2515.full.pdf+html
PubMed ID:17013995

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