Header

UZH-Logo

Maintenance Infos

Role of Peroxisome Proliferator-Activated Receptor γ and Estrogen Receptors in Mediating the Anti-Mitogenic Actions of Phytoestrogens


Boogen, E M. Role of Peroxisome Proliferator-Activated Receptor γ and Estrogen Receptors in Mediating the Anti-Mitogenic Actions of Phytoestrogens. 2008, Clinic for Reproductive Endocrinology, Faculty of Medicine.

Abstract

Most Western countries face high and increasing rates of cardiovascular disease (CVD). Each year, heart disease kills more people than cancer. The increasing risk of CVD in woman after postmenopausal changes suggests that estrogen has cardioprotective effects. It is well known that estrogen binds to estrogen receptors (ER) and mediates its effects via different pathways and thereby influences various systems in the male and female physiology.
Phytoestrogens, natural constituents of many plants, seeds and grains are oestrogen like ligands with numerous effects to the human body. They are similar to estrogens and bind to ERs, they are supposed to mimic the effects of estrogens and mediate these acitivities via ERs. However, recent findings suggest that phytoestrogens bind to PPAR- γ receptors. Together with the fact, that the protective effects of the phytoestrogen genistein are not blocked by ER antagonist and that PPAR- γ agonists are also cardioprotective we investigated, whether the protective action of phytoestrogens may be PPAR- γ mediated.

Abstract

Most Western countries face high and increasing rates of cardiovascular disease (CVD). Each year, heart disease kills more people than cancer. The increasing risk of CVD in woman after postmenopausal changes suggests that estrogen has cardioprotective effects. It is well known that estrogen binds to estrogen receptors (ER) and mediates its effects via different pathways and thereby influences various systems in the male and female physiology.
Phytoestrogens, natural constituents of many plants, seeds and grains are oestrogen like ligands with numerous effects to the human body. They are similar to estrogens and bind to ERs, they are supposed to mimic the effects of estrogens and mediate these acitivities via ERs. However, recent findings suggest that phytoestrogens bind to PPAR- γ receptors. Together with the fact, that the protective effects of the phytoestrogen genistein are not blocked by ER antagonist and that PPAR- γ agonists are also cardioprotective we investigated, whether the protective action of phytoestrogens may be PPAR- γ mediated.

Statistics

Downloads

203 downloads since deposited on 24 Feb 2009
62 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Dissertation
Referees:Dubey R K, Imthurn B
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Reproductive Endocrinology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2008
Deposited On:24 Feb 2009 15:16
Last Modified:05 Apr 2016 13:06
Number of Pages:50

Download

Preview Icon on Download
Preview
Filetype: PDF
Size: 1MB

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations