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Estradiol induces mitogenesis in human progenitor endothelial cells (PECs) by upregulating cyclins and downregulating p21


Baruscotti, I; Gillespie, D G; Jackson, E K; Imthurn, B (2008). Estradiol induces mitogenesis in human progenitor endothelial cells (PECs) by upregulating cyclins and downregulating p21. In: 7th Day of Clinical Research, University Hospital Zurich, 27 March 2008 - 29 March 2008.

Abstract

Circulating progenitor endothelial cells (PECs) play a critical role in repairing damaged endothelial layer. Since estradiol is vasoprotective (1), it may promote vascular endothelial recovery by inducing PEC-proliferation. Here we investigated the growth effects of estradiol on human PECs and the intracellular mechanisms involved.

Abstract

Circulating progenitor endothelial cells (PECs) play a critical role in repairing damaged endothelial layer. Since estradiol is vasoprotective (1), it may promote vascular endothelial recovery by inducing PEC-proliferation. Here we investigated the growth effects of estradiol on human PECs and the intracellular mechanisms involved.

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Additional indexing

Item Type:Conference or Workshop Item (Other), refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Reproductive Endocrinology
Dewey Decimal Classification:610 Medicine & health
Language:German
Event End Date:29 March 2008
Deposited On:24 Feb 2011 16:10
Last Modified:06 Dec 2017 18:48

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