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Endogenous neural progenitor cells as therapeutic target after spinal cord injury


Obermair, F J; Schröter, A; Thallmair, M (2008). Endogenous neural progenitor cells as therapeutic target after spinal cord injury. Physiology, 23(5):296-304.

Abstract

Growing knowledge about the role of neural progenitor cells supports the hope that stem cell-based therapeutic approaches aimed at restoring function in the lesioned central nervous system can be established. Possible therapies for promoting recovery after spinal cord injury include stimulating the formation of neurons and glial cells by endogenous progenitor cells. This article reviews the current knowledge about the nature of adult progenitor cells in the intact and injured spinal cord and summarizes possibilities and limitations of cellular replacement strategies based on manipulations of endogenous spinal cord progenitor cells and their environment.

Abstract

Growing knowledge about the role of neural progenitor cells supports the hope that stem cell-based therapeutic approaches aimed at restoring function in the lesioned central nervous system can be established. Possible therapies for promoting recovery after spinal cord injury include stimulating the formation of neurons and glial cells by endogenous progenitor cells. This article reviews the current knowledge about the nature of adult progenitor cells in the intact and injured spinal cord and summarizes possibilities and limitations of cellular replacement strategies based on manipulations of endogenous spinal cord progenitor cells and their environment.

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37 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Brain Research Institute
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:October 2008
Deposited On:27 Feb 2009 14:56
Last Modified:06 Dec 2017 18:53
Publisher:American Physiological Society
ISSN:1548-9221
Publisher DOI:https://doi.org/10.1152/physiol.00017.2008
PubMed ID:18927205

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