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Nogo-A: Its role in axon regeneration


Schwab, M E; Ghosh, A (2008). Nogo-A: Its role in axon regeneration. In: Squire, L R. Encyclopedia of neuroscience. Amsterdam, NL: Elsevier, 1199-1204.

Abstract

Nogo-A, a membrane protein enriched in central nervous system (CNS) myelin, is a potent inhibitor of regeneration and plasticity in the adult CNS. Adult spinal cord-injured animals show significant behavioral recovery, long-distance regeneration, and compensatory fiber growth after Nogo-A neutralization using clinically relevant methods. Here we review the findings over the past two decades, which are the key to understanding the significance of the inhibitory protein Nogo-A in axon regeneration.

Abstract

Nogo-A, a membrane protein enriched in central nervous system (CNS) myelin, is a potent inhibitor of regeneration and plasticity in the adult CNS. Adult spinal cord-injured animals show significant behavioral recovery, long-distance regeneration, and compensatory fiber growth after Nogo-A neutralization using clinically relevant methods. Here we review the findings over the past two decades, which are the key to understanding the significance of the inhibitory protein Nogo-A in axon regeneration.

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Item Type:Book Section, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Brain Research Institute
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2008
Deposited On:06 Mar 2009 09:52
Last Modified:05 Apr 2016 13:10
Publisher:Elsevier
ISBN: 978-0-08-045046-9
Official URL:http://www.sciencedirect.com/science/referenceworks/9780080450469
Related URLs:http://www.elsevierdirect.com/brochures/ens/index.html (Publisher)

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