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The serotype-specific glucose side chain of rhamnose–glucose polysaccharides is essential for adsorption of bacteriophage M102 to Streptococcus mutans


Shibata, Y; Yamashity, Y; van der Ploeg, J R (2009). The serotype-specific glucose side chain of rhamnose–glucose polysaccharides is essential for adsorption of bacteriophage M102 to Streptococcus mutans. FEMS Microbiology Letters, 294(1):68-73.

Abstract

Bacteriophage M102 is a virulent siphophage that propagates in some serotype c Streptococcus mutans strains, but not in S. mutans of serotype e, f or k. The serotype of S. mutans is determined by the glucose side chain of rhamnose–glucose polysaccharide (RGP). Because the first step in the bacteriophage infection process is adsorption of the phage, it was investigated whether the serotype specificity of phage M102 was determined by adsorption. M102 adsorbed to all tested serotype c strains, but not to strains of different serotypes. Streptococcus mutans serotype c mutants defective in the synthesis of the glucose side chain of RGP failed to adsorb phage M102. These results suggest that the glucose side chain of RGP acts as a receptor for phage M102.

Abstract

Bacteriophage M102 is a virulent siphophage that propagates in some serotype c Streptococcus mutans strains, but not in S. mutans of serotype e, f or k. The serotype of S. mutans is determined by the glucose side chain of rhamnose–glucose polysaccharide (RGP). Because the first step in the bacteriophage infection process is adsorption of the phage, it was investigated whether the serotype specificity of phage M102 was determined by adsorption. M102 adsorbed to all tested serotype c strains, but not to strains of different serotypes. Streptococcus mutans serotype c mutants defective in the synthesis of the glucose side chain of RGP failed to adsorb phage M102. These results suggest that the glucose side chain of RGP acts as a receptor for phage M102.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Dental Medicine > Institute of Oral Biology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:1 May 2009
Deposited On:08 Apr 2009 12:11
Last Modified:26 Jan 2017 08:44
Publisher:Wiley-Blackwell
ISSN:0378-1097
Additional Information:The definitive version is available at www.blackwell-synergy.com at http://www3.interscience.wiley.com/cgi-bin/fulltext/122259812/PDFSTART
Publisher DOI:https://doi.org/10.1111/j.1574-6968.2009.01546.x
Official URL:http://www3.interscience.wiley.com/cgi-bin/fulltext/122259812/PDFSTART
Related URLs:http://www3.interscience.wiley.com/journal/118512081/home (Publisher)

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