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Zur Bedeutung der haemotrophen Mycoplasmen in der Veterinärmedizin unter besonderer Berücksichtigung der Mycoplasma suis-Infektion beim Schwein


Hoelzle, L E (2007). Zur Bedeutung der haemotrophen Mycoplasmen in der Veterinärmedizin unter besonderer Berücksichtigung der Mycoplasma suis-Infektion beim Schwein. Berliner und Münchener Tierärztliche Wochenschrift, 120(1-2):34-41.

Abstract

Phylogenetic investigations led to the definition of a new group of bacteria called haemotrophic mycoplasmas (haemoplasmas).The life cycle of said globally spread bacteria is dependent on their intimate contact with their host erythrocytes. Illnesses showing symptoms of a haemolytic anaemia are usually found in cats and swine. Haemoplasmas are small pleomorphic bacteria (0.3-3 microm) with a very small genome (745-1245 kbp).To date there is very limited knowledge on their biology and the host-bacteria-interactions (immune response, pathogenesis) since these bacteria are yet not culturable. Applying modern molecular biological techniques we succeeded during the last few years in gaining new facts on the antigen structure of M.suis as well as on the immunology and pathogenesis of the porcine eperythrozoonosis.Thus we detected three main antigens two of which we expressed recombinant in our laboratory. These surface-exposed antigens serve as a basis for establishing serologic assays, and are vaccine candidates, too. Preliminary studies allowed us to find the function of an adhesin of M. suis for one of the two proteins.

Abstract

Phylogenetic investigations led to the definition of a new group of bacteria called haemotrophic mycoplasmas (haemoplasmas).The life cycle of said globally spread bacteria is dependent on their intimate contact with their host erythrocytes. Illnesses showing symptoms of a haemolytic anaemia are usually found in cats and swine. Haemoplasmas are small pleomorphic bacteria (0.3-3 microm) with a very small genome (745-1245 kbp).To date there is very limited knowledge on their biology and the host-bacteria-interactions (immune response, pathogenesis) since these bacteria are yet not culturable. Applying modern molecular biological techniques we succeeded during the last few years in gaining new facts on the antigen structure of M.suis as well as on the immunology and pathogenesis of the porcine eperythrozoonosis.Thus we detected three main antigens two of which we expressed recombinant in our laboratory. These surface-exposed antigens serve as a basis for establishing serologic assays, and are vaccine candidates, too. Preliminary studies allowed us to find the function of an adhesin of M. suis for one of the two proteins.

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Additional indexing

Other titles:Significance of haemotrophic mycoplasmas in veterinary medicine with particular regard to the Mycoplasma suis infection in swine
Item Type:Journal Article, refereed, further contribution
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Bacteriology
Dewey Decimal Classification:570 Life sciences; biology
Date:2007
Deposited On:05 Jun 2009 12:10
Last Modified:26 Jan 2017 08:44
Publisher:Schlütersche Verlagsgesellschaft
ISSN:0005-9366
Publisher DOI:https://doi.org/10.2376/0005-9366-120-34
Official URL:http://vetline.de/facharchiv/veterinary_public_health/bmtw/11809493.htm
PubMed ID:17290941

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