Header

UZH-Logo

Maintenance Infos

Transposable elements as genomic diseases


Wagner, A (2009). Transposable elements as genomic diseases. Molecular BioSystems, 5(1):32-35.

Abstract

Human disease agents can get transmitted both horizontally--through infection--and vertically--from parent to offspring. Depending on details of their evolutionary dynamics, they may increase or decrease in virulence over time. The evolutionary dynamics of bacterial transposable elements resembles that of human pathogens in these and other respects. I here briefly highlight similarities and differences in the two evolutionary processes. I also suggest that an epidemiological perspective, combined with future estimates of parameters of transposable element evolution from hundreds of genomes, may yield insights into the forces that maintain transposable elements in bacterial populations.

Abstract

Human disease agents can get transmitted both horizontally--through infection--and vertically--from parent to offspring. Depending on details of their evolutionary dynamics, they may increase or decrease in virulence over time. The evolutionary dynamics of bacterial transposable elements resembles that of human pathogens in these and other respects. I here briefly highlight similarities and differences in the two evolutionary processes. I also suggest that an epidemiological perspective, combined with future estimates of parameters of transposable element evolution from hundreds of genomes, may yield insights into the forces that maintain transposable elements in bacterial populations.

Statistics

Citations

16 citations in Web of Science®
16 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

46 downloads since deposited on 23 Jun 2009
15 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Department of Biochemistry
07 Faculty of Science > Department of Biochemistry
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:2009
Deposited On:23 Jun 2009 14:02
Last Modified:06 Dec 2017 20:04
Publisher:Royal Society of Chemistry
ISSN:1742-2051
Publisher DOI:https://doi.org/10.1039/b814624c
PubMed ID:19081928

Download

Download PDF  'Transposable elements as genomic diseases'.
Preview
Content: Accepted Version
Filetype: PDF
Size: 1MB
View at publisher