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Hypocretin-1 (orexin A) deficiency in acute traumatic brain injury


Baumann, C R; Stocker, R; Imhof, H G; Trentz, O; Hersberger, M; Mignot, E; Bassetti, C L (2005). Hypocretin-1 (orexin A) deficiency in acute traumatic brain injury. Neurology, 65(1):147-149.

Abstract

Hypocretin-1 is involved in the regulation of the sleep-wake cycle. The authors prospectively assessed CSF hypocretin-1 levels in 44 consecutive patients with acute traumatic brain injury (TBI). Compared with controls, hypocretin-1 levels were abnormally lower in 95% of patients with moderate to severe TBI and in 97% of patients with posttraumatic brain CT changes. Hypocretin-1 deficiency after TBI may reflect hypothalamic damage and be linked with the frequent development of posttraumatic sleep-wake disorders.

Abstract

Hypocretin-1 is involved in the regulation of the sleep-wake cycle. The authors prospectively assessed CSF hypocretin-1 levels in 44 consecutive patients with acute traumatic brain injury (TBI). Compared with controls, hypocretin-1 levels were abnormally lower in 95% of patients with moderate to severe TBI and in 97% of patients with posttraumatic brain CT changes. Hypocretin-1 deficiency after TBI may reflect hypothalamic damage and be linked with the frequent development of posttraumatic sleep-wake disorders.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Intensive Care Medicine
Dewey Decimal Classification:610 Medicine & health
Date:2005
Deposited On:16 Sep 2009 11:52
Last Modified:05 Apr 2016 13:18
Publisher:American Academy of Neurology
ISSN:0028-3878
Publisher DOI:https://doi.org/10.1212/01.wnl.0000167605.02541.f2
Official URL:http://www.neurology.org/cgi/content/full/65/1/147
PubMed ID:16009905

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