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Cerebral vasospasm following subarachnoid hemorrhage: time for a new world of thought


Pluta, R M; Hansen-Schwartz, J; Dreier, J; Vajkoczy, P; Macdonald, R L; Nishizawa, S; Kasuya, H; Wellmann, G; Keller, E; Zauner, A; Dorsch, N; Clark, J; Ono, S; Kiris, T; Leroux, P; Zhang, J H (2009). Cerebral vasospasm following subarachnoid hemorrhage: time for a new world of thought. Neurological Research, 31(2):151-158.

Abstract

Objective: Delayed cerebral vasospasm has long been recog-nized as an important cause of poor outcome after an otherwise successful treatment of a ruptured intracranial aneurysm, but it remains a pathophysiological enigma despite intensive research for more than half a century.
Method: Summarized in this review are highlights of research from North America, Europe and Asia reflecting recent advances in the understanding of delayed ischemic deficit.
Result: It will focus on current accepted mechanisms and on new frontiers in vasospasm research.
Conclusion: A key issue is the recognition of events other than arterial narrowing such as early brain injury and cortical spreading depression and of their contribution to overall mortality and morbidity.

Abstract

Objective: Delayed cerebral vasospasm has long been recog-nized as an important cause of poor outcome after an otherwise successful treatment of a ruptured intracranial aneurysm, but it remains a pathophysiological enigma despite intensive research for more than half a century.
Method: Summarized in this review are highlights of research from North America, Europe and Asia reflecting recent advances in the understanding of delayed ischemic deficit.
Result: It will focus on current accepted mechanisms and on new frontiers in vasospasm research.
Conclusion: A key issue is the recognition of events other than arterial narrowing such as early brain injury and cortical spreading depression and of their contribution to overall mortality and morbidity.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurosurgery
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:March 2009
Deposited On:25 Aug 2009 08:59
Last Modified:21 Nov 2017 14:17
Publisher:Maney Publishing
ISSN:0161-6412
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1179/174313209X393564
PubMed ID:19298755

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