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Prevention and treatment of Encephalitozoon cuniculi infection in rabbits with fenbendazole


Suter, C; Müller-Doblies, U U; Hatt, Jean-Michel; Deplazes, Peter (2001). Prevention and treatment of Encephalitozoon cuniculi infection in rabbits with fenbendazole. Veterinary Record, 148(15):478-480.

Abstract

The efficacy of fenbendazole for preventing an experimental infection of Encephalitozoon cuniculi and for eliminating the spores from the central nervous system of naturally infected rabbits was investigated. Fenbendazole (20 mg/kg bodyweight daily) was administered from seven days before until two or 21 days after rabbits had been infected orally with 10(6) spores of E. cuniculi. Both regimens were effective in preventing the establishment of the parasites, as demonstrated by negative parasitic-specific serology and by the failure to isolate the parasite from brain tissue. In naturally infected, seropositive rabbits, parasites were successfully isolated from seven of nine untreated animals, but not from the brain tissue of eight animals treated with fenbendazole-medicated pellets for four weeks.

Abstract

The efficacy of fenbendazole for preventing an experimental infection of Encephalitozoon cuniculi and for eliminating the spores from the central nervous system of naturally infected rabbits was investigated. Fenbendazole (20 mg/kg bodyweight daily) was administered from seven days before until two or 21 days after rabbits had been infected orally with 10(6) spores of E. cuniculi. Both regimens were effective in preventing the establishment of the parasites, as demonstrated by negative parasitic-specific serology and by the failure to isolate the parasite from brain tissue. In naturally infected, seropositive rabbits, parasites were successfully isolated from seven of nine untreated animals, but not from the brain tissue of eight animals treated with fenbendazole-medicated pellets for four weeks.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Language:English
Date:2001
Deposited On:28 Apr 2008 07:29
Last Modified:01 Jun 2016 11:18
Publisher:British Veterinary Association
ISSN:0042-4900
Publisher DOI:https://doi.org/10.1136/vr.148.15.478
Related URLs:http://veterinaryrecord.bvapublications.com/cgi/content/abstract/148/15/478 (Publisher)
PubMed ID:11334074

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