Header

UZH-Logo

Maintenance Infos

Mutations affecting development of the notochord in zebrafish.


Stemple, D L; Solnica-Krezel, L; Zwartkruis, F J T; Neuhauss, S C F; Schier, A F; Malicki, J; Stainier, D Y; Abdelilah, S; Rangini, Z; Mountcastle-Shah, E; Driever, W (1996). Mutations affecting development of the notochord in zebrafish. Development, 123:117-128.

Abstract

The notochord is critical for the normal development of vertebrate embryos. It serves both as the major skeletal element of the embryo and as a signaling source for the establishment of pattern within the neurectoderm, the paraxial mesoderm and other tissues. In a large-scale systematic screen of mutations affecting embryogenesis in zebrafish we identified 65 mutations that fall into 29 complementation groups, each leading to a defect in the formation and/or maintenance of the notochord. These mutations produce phenotypic abnormalities at numerous stages of notochord development, thereby establishing a phenotypic pathway, which in turn suggests a genetic pathway for the development of the notochord. Perturbations within adjacent tissues in mutant embryos further indicate the importance of notochord-derived signals for patterning within the embryo and suggest that these mutations will yield additional insight into the cues that regulate these patterning processes.

Abstract

The notochord is critical for the normal development of vertebrate embryos. It serves both as the major skeletal element of the embryo and as a signaling source for the establishment of pattern within the neurectoderm, the paraxial mesoderm and other tissues. In a large-scale systematic screen of mutations affecting embryogenesis in zebrafish we identified 65 mutations that fall into 29 complementation groups, each leading to a defect in the formation and/or maintenance of the notochord. These mutations produce phenotypic abnormalities at numerous stages of notochord development, thereby establishing a phenotypic pathway, which in turn suggests a genetic pathway for the development of the notochord. Perturbations within adjacent tissues in mutant embryos further indicate the importance of notochord-derived signals for patterning within the embryo and suggest that these mutations will yield additional insight into the cues that regulate these patterning processes.

Statistics

Citations

140 citations in Web of Science®
132 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

188 downloads since deposited on 11 Feb 2008
18 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:1 December 1996
Deposited On:11 Feb 2008 12:13
Last Modified:21 Nov 2017 13:20
Publisher:Company of Biologists
ISSN:0950-1991
PubMed ID:9007234

Download

Download PDF  'Mutations affecting development of the notochord in zebrafish.'.
Preview
Content: Published Version
Filetype: PDF
Size: 690kB