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A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory


Haditsch, U; Leone, D P; Farinelli, M; Chrostek-Grashoff, A; Brakebusch, A; Mansuy, I M; McConnell, S K; Palmer, T (2009). A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory. Molecular and Cellular Neuroscience, 41(4):409-419.

Abstract

Rac1 is a member of the Rho family of small GTPases that are important for structural aspects of the mature neuronal synapse including basal spine density and shape, activity-dependent spine enlargement, and AMPA receptor clustering in vitro. Here we demonstrate that selective elimination of Rac1 in excitatory neurons in the forebrain in vivo not only affects spine structure, but also impairs synaptic plasticity in the hippocampus with consequent defects in hippocampus-dependent spatial learning. Furthermore, Rac1 mutants display deficits in working/episodic-like memory in the delayed matching-to-place (DMP) task suggesting that Rac1 is a central regulator of rapid encoding of novel spatial information in vivo.

Abstract

Rac1 is a member of the Rho family of small GTPases that are important for structural aspects of the mature neuronal synapse including basal spine density and shape, activity-dependent spine enlargement, and AMPA receptor clustering in vitro. Here we demonstrate that selective elimination of Rac1 in excitatory neurons in the forebrain in vivo not only affects spine structure, but also impairs synaptic plasticity in the hippocampus with consequent defects in hippocampus-dependent spatial learning. Furthermore, Rac1 mutants display deficits in working/episodic-like memory in the delayed matching-to-place (DMP) task suggesting that Rac1 is a central regulator of rapid encoding of novel spatial information in vivo.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Brain Research Institute
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:August 2009
Deposited On:23 Nov 2009 13:21
Last Modified:05 Apr 2016 13:34
Publisher:Elsevier
ISSN:1044-7431
Publisher DOI:https://doi.org/10.1016/j.mcn.2009.04.005
PubMed ID:19394428

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