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Resttaschentiefe nach parodontaler Regenerationstherapie : klinische Relevanz und Interpretation von Meta-Analysen-Daten


Schmidlin, P R; Hauri, D; Krähenmann, M A; Puhan, M A; Attin, T (2009). Resttaschentiefe nach parodontaler Regenerationstherapie : klinische Relevanz und Interpretation von Meta-Analysen-Daten. Schweizer Monatsschrift für Zahnmedizin SMfZ, 119(3):224-231.

Abstract

Meta-analyses allow to combine results systematically and to obtain more precise quantitative results on the efficacy of a therapy. For the clinician, the comparison of two therapy modalities is particularly of interest. Several meta-analyses exist in the field of periodontal regenerative procedures. The problem is that the results are difficult to interpret for the clinician. It is only the clinical effect that can indicate the superiority of a certain treatment modality, e.g. remaining periodontal pockets. The aim of the present systematic review was the re-evaluation of studies of existing meta-analyses and to determine the probability of remaining periodontal pockets of more than 3 respectively 5 mm after active therapy. The probability of remaining periodontal pockets over 3 respectively 5 mm was significantly higher after periodontal flap procedure without regenerative procedures, compared to guided tissue regeneration (GTR) or the use of enamel matrix derivatives. Moreover, the probability of remaining pockets over 3 mm was with GTR on average 57% and with the use of enamel maxtrix derivatives 74%. Using the cut-off value of 5 mm this probability was reduced to 8 and 17%, respectively. A new clinical attachment that was less than 50% of the original level was to be expected in 29% (GTR) and 15% using enamel matrix derivatives. This statistical interpretation permits not only the clinician, but also the patient to compare the efficacy of the different treatment modalities using the probability of primary clinical effect outcomes.

Abstract

Meta-analyses allow to combine results systematically and to obtain more precise quantitative results on the efficacy of a therapy. For the clinician, the comparison of two therapy modalities is particularly of interest. Several meta-analyses exist in the field of periodontal regenerative procedures. The problem is that the results are difficult to interpret for the clinician. It is only the clinical effect that can indicate the superiority of a certain treatment modality, e.g. remaining periodontal pockets. The aim of the present systematic review was the re-evaluation of studies of existing meta-analyses and to determine the probability of remaining periodontal pockets of more than 3 respectively 5 mm after active therapy. The probability of remaining periodontal pockets over 3 respectively 5 mm was significantly higher after periodontal flap procedure without regenerative procedures, compared to guided tissue regeneration (GTR) or the use of enamel matrix derivatives. Moreover, the probability of remaining pockets over 3 mm was with GTR on average 57% and with the use of enamel maxtrix derivatives 74%. Using the cut-off value of 5 mm this probability was reduced to 8 and 17%, respectively. A new clinical attachment that was less than 50% of the original level was to be expected in 29% (GTR) and 15% using enamel matrix derivatives. This statistical interpretation permits not only the clinician, but also the patient to compare the efficacy of the different treatment modalities using the probability of primary clinical effect outcomes.

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Additional indexing

Other titles:Residual pocket depth after periodontal regenerative procedures. Clinical relevance and interpretation of meta-analyses data
Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Center for Dental Medicine > Clinic for Preventive Dentistry, Periodontology and Cariology
Dewey Decimal Classification:610 Medicine & health
Language:German
Date:March 2009
Deposited On:10 Dec 2009 10:34
Last Modified:05 Apr 2016 13:35
Publisher:Schweizerische Zahnärzte-Gesellschft
ISSN:0256-2855
Free access at:Official URL. An embargo period may apply.
Official URL:http://www.sso.ch/doc/doc_download.cfm?uuid=EA3BCC951185B8C4BA5AC5E9A461EF87&&IRACER_AUTOLINK&&
PubMed ID:19408526

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