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Design of protein-protein interaction inhibitors based on protein epitope mimetics - Zurich Open Repository and Archive


Robinson, J A (2009). Design of protein-protein interaction inhibitors based on protein epitope mimetics. ChemBioChem, 10(6):971-973.

Abstract

On the scaffold: Grafting protein epitopes onto conformationally designed scaffolds represents a very promising approach to protein ligand design, with potential applications in many areas of chemical biology and molecular medicine. The highlighted article describes the design and anticancer activity of novel p53/MDM2 inhibitors built upon a scorpion toxin scaffold. Other approaches to protein epitope mimetics are also briefly discussed.

Abstract

On the scaffold: Grafting protein epitopes onto conformationally designed scaffolds represents a very promising approach to protein ligand design, with potential applications in many areas of chemical biology and molecular medicine. The highlighted article describes the design and anticancer activity of novel p53/MDM2 inhibitors built upon a scorpion toxin scaffold. Other approaches to protein epitope mimetics are also briefly discussed.

Citations

24 citations in Web of Science®
27 citations in Scopus®
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121 downloads since deposited on 30 Dec 2009
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:17 April 2009
Deposited On:30 Dec 2009 09:16
Last Modified:05 Apr 2016 13:36
Publisher:Wiley VCH
ISSN:1439-4227
Publisher DOI:https://doi.org/10.1002/cbic.200900055
PubMed ID:19266524

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