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Glucose reverses fasting-induced activation in the arcuate nucleus of mice


Becskei, C; Lutz, T A; Riediger, T (2008). Glucose reverses fasting-induced activation in the arcuate nucleus of mice. NeuroReport, 19(1):105-109.

Abstract

The hypothalamic arcuate nucleus is an important target for metabolic and hormonal signals controlling food intake. As demonstrated by c-Fos studies, arcuate neurons are activated in food deprived mice, while refeeding reverses the fasting-induced activation. To evaluate whether an increase in blood glucose has an inhibitory effect on these neurons, we analyzed the c-Fos response to an intraperitoneal glucose injection in fasted mice. This treatment increased blood glucose levels twofold and reduced 2h food intake. Similar to refeeding, it also reversed the fasting-induced activation in the arcuate nucleus. Therefore, an increase in blood glucose might be an important feeding-related signal acting via the arcuate nucleus to oppose orexigenic stimuli.

Abstract

The hypothalamic arcuate nucleus is an important target for metabolic and hormonal signals controlling food intake. As demonstrated by c-Fos studies, arcuate neurons are activated in food deprived mice, while refeeding reverses the fasting-induced activation. To evaluate whether an increase in blood glucose has an inhibitory effect on these neurons, we analyzed the c-Fos response to an intraperitoneal glucose injection in fasted mice. This treatment increased blood glucose levels twofold and reduced 2h food intake. Similar to refeeding, it also reversed the fasting-induced activation in the arcuate nucleus. Therefore, an increase in blood glucose might be an important feeding-related signal acting via the arcuate nucleus to oppose orexigenic stimuli.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Physiology
04 Faculty of Medicine > Center for Integrative Human Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:8 January 2008
Deposited On:20 May 2008 09:17
Last Modified:05 Apr 2016 12:23
Publisher:Lippincott Wiliams & Wilkins
ISSN:0959-4965
Additional Information:This is a non-final version of an article published in final form in NeuroReport 2008, 19(1):105-109.
Publisher DOI:https://doi.org/10.1097/WNR.0b013e3282f380a2
Official URL:http://www.neuroreport.com/pt/re/neuroreport/abstract.00001756-200801080-00020.htm
PubMed ID:18281902

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