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Syntheses and biological evaluation of iriomoteolide 3a and analogues


Cribiú, R; Jäger, C; Nevado, C (2009). Syntheses and biological evaluation of iriomoteolide 3a and analogues. Angewandte Chemie Internationale Edition, 48(46):8780-8783.

Abstract

Metathesis on stage: A combined cross-metathesis (CM)/ring-closing metathesis (RCM) approach has led to the stereocontrolled synthesis of iriomoteolide 3a, a smaller but equally cytotoxic congener of amphidinolides. Chemical editing of the molecule has provided non-natural analogues which have comparable anticancer activity to that of the natural product, thereby allowing the iriomoteolides to be used as probe molecules in chemical biology.

Abstract

Metathesis on stage: A combined cross-metathesis (CM)/ring-closing metathesis (RCM) approach has led to the stereocontrolled synthesis of iriomoteolide 3a, a smaller but equally cytotoxic congener of amphidinolides. Chemical editing of the molecule has provided non-natural analogues which have comparable anticancer activity to that of the natural product, thereby allowing the iriomoteolides to be used as probe molecules in chemical biology.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:2009
Deposited On:15 Jan 2010 10:46
Last Modified:16 Dec 2016 11:37
Publisher:Wiley-VCH Verlag
ISSN:1433-7851
Publisher DOI:https://doi.org/10.1002/anie.200903379

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