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Engineering of biologically active living heart valve leaflets using human umbilical cord-derived progenitor cells


Schmidt, D; Mol, A; Odermatt, B; Neuenschwander, S; Breymann, C; Gössi, M; Genoni, M; Zund, G; Hoerstrup, S P (2006). Engineering of biologically active living heart valve leaflets using human umbilical cord-derived progenitor cells. Tissue Engineering, 12(11):3223-3232.

Abstract

This study demonstrates the engineering of biologically active heart valve leaflets using prenatally available human umbilical cord-derived progenitor cells as the only cell source. Wharton's Jelly-derived cells and umbilical cord blood-derived endothelial progenitor cells were subsequently seeded on biodegradable scaffolds and cultured in a biomimetic system under biochemical or mechanical stimulation or both. Depending on the stimulation, leaflets showed mature layered tissue formation with functional endothelia and extracellular matrix production comparable with that of native tissues. This demonstrates the feasibility of heart valve leaflet fabrication from prenatal umbilical cord-derived progenitor cells as a further step in overcoming the lack of living autologous replacements with growth and regeneration potential for the repair of congenital malformation.

Abstract

This study demonstrates the engineering of biologically active heart valve leaflets using prenatally available human umbilical cord-derived progenitor cells as the only cell source. Wharton's Jelly-derived cells and umbilical cord blood-derived endothelial progenitor cells were subsequently seeded on biodegradable scaffolds and cultured in a biomimetic system under biochemical or mechanical stimulation or both. Depending on the stimulation, leaflets showed mature layered tissue formation with functional endothelia and extracellular matrix production comparable with that of native tissues. This demonstrates the feasibility of heart valve leaflet fabrication from prenatal umbilical cord-derived progenitor cells as a further step in overcoming the lack of living autologous replacements with growth and regeneration potential for the repair of congenital malformation.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Research
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2006
Deposited On:08 Dec 2009 13:52
Last Modified:06 Dec 2017 22:22
Publisher:Mary Ann Liebert
ISSN:1076-3279
Publisher DOI:https://doi.org/10.1089/ten.2006.12.3223
Related URLs:http://www.mate.tue.nl/mate/showabstract.php/7133
PubMed ID:17518636

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