Header

UZH-Logo

Maintenance Infos

Targeting G-quadruplex DNA with small molecules


Luedtke, N W (2009). Targeting G-quadruplex DNA with small molecules. CHIMIA International Journal for Chemistry, 63(3):134-139.

Abstract

Despite a recent explosion of interest in G-quadruplex DNA, most fundamental questions regarding the possible presence and function of these intriguing structures in vivo remain unanswered. Cell-permeable G-quadruplex specific probes should provide researchers with new tools for studying these alternately folded DNA structures and their potential involvement in gene expression, chromosome stability, viral integration, and recombination. In this review, a survey of the binding affinity, specificity, and biological/pharmacological activities of some well-characterized G-quadruplex ligands is presented along with the potential importance of G-quadruplex DNA in vivo.

Abstract

Despite a recent explosion of interest in G-quadruplex DNA, most fundamental questions regarding the possible presence and function of these intriguing structures in vivo remain unanswered. Cell-permeable G-quadruplex specific probes should provide researchers with new tools for studying these alternately folded DNA structures and their potential involvement in gene expression, chromosome stability, viral integration, and recombination. In this review, a survey of the binding affinity, specificity, and biological/pharmacological activities of some well-characterized G-quadruplex ligands is presented along with the potential importance of G-quadruplex DNA in vivo.

Statistics

Citations

54 citations in Web of Science®
56 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

205 downloads since deposited on 08 Jan 2010
22 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, not refereed, further contribution
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:2009
Deposited On:08 Jan 2010 11:59
Last Modified:26 Jan 2017 08:45
Publisher:Swiss Chemical Society
ISSN:0009-4293
Additional Information:Copyright ©Swiss Chemical Society: CHIMIA, Volume 63, Number 3, March 2009
Publisher DOI:https://doi.org/10.2533/chimia.2009.134

Download

Download PDF  'Targeting G-quadruplex DNA with small molecules'.
Preview
Filetype: PDF
Size: 1MB
View at publisher