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CPEB3 is associated with human episodic memory


Vogler, C; Spalek, K; Aerni, A; Demougin, P; Müller, A; Huynh, K D; Papassotiropoulos, A; de Quervain, D J F (2009). CPEB3 is associated with human episodic memory. Frontiers in Behavioral Neuroscience:3:4.

Abstract

Cytoplasmic polyadenylation element-binding (CPEB) proteins are crucial for synaptic plasticity and memory in model organisms. A highly conserved, mammalian-specific short intronic sequence within CPEB3 has been identified as a ribozyme with self-cleavage properties. In humans, the ribozyme sequence is polymorphic and harbors a single nucleotide polymorphism that influences cleavage activity of the ribozyme. Here we show that this variation is related to performance in an episodic memory task and that the effect of the variation depends on the emotional valence of the presented material. Our data suggest a role for human CPEB3 in human episodic memory.

Abstract

Cytoplasmic polyadenylation element-binding (CPEB) proteins are crucial for synaptic plasticity and memory in model organisms. A highly conserved, mammalian-specific short intronic sequence within CPEB3 has been identified as a ribozyme with self-cleavage properties. In humans, the ribozyme sequence is polymorphic and harbors a single nucleotide polymorphism that influences cleavage activity of the ribozyme. Here we show that this variation is related to performance in an episodic memory task and that the effect of the variation depends on the emotional valence of the presented material. Our data suggest a role for human CPEB3 in human episodic memory.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute for Regenerative Medicine (IREM)
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2009
Deposited On:06 Jan 2010 13:50
Last Modified:06 Dec 2017 22:52
Publisher:Frontiers Research Foundation
ISSN:1662-5153
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.3389/neuro.08.004.2009
PubMed ID:19503753

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