Header

UZH-Logo

Maintenance Infos

Regulatory NK-cell functions in inflammation and autoimmunity


Lünemann, A; Lünemann, J D; Münz, C (2009). Regulatory NK-cell functions in inflammation and autoimmunity. Molecular Medicine, 15(9-10):352-358.

Abstract

Natural killer (NK) cells were viewed traditionally as cytotoxic effector cells whose rapid killing of infected and transformed cells without preactivation provides a first line of defense prior to the initiation of an adaptive immune response against infection and tumor development. However, it has become clear that NK cells interact with various components of the immune system, and therefore have the potential to function as regulatory cells. While NK cells can assist in dendritic cell (DC) maturation and T-cell polarization, increasing evidence indicates that NK cells can also prevent and limit adaptive (auto) immune responses via killing of autologous myeloid and lymphoid cells. Investigating immunoregulatory NK-cell functions might generate exciting insights into the reciprocal regulation between NK-cell-mediated innate immunity and adaptive immune responses, improve our capacity to monitor these cells as surrogate markers for disease activity and treatment responses in autoimmune diseases, and, perhaps, provide new prospects for NK cell-directed therapies.

Abstract

Natural killer (NK) cells were viewed traditionally as cytotoxic effector cells whose rapid killing of infected and transformed cells without preactivation provides a first line of defense prior to the initiation of an adaptive immune response against infection and tumor development. However, it has become clear that NK cells interact with various components of the immune system, and therefore have the potential to function as regulatory cells. While NK cells can assist in dendritic cell (DC) maturation and T-cell polarization, increasing evidence indicates that NK cells can also prevent and limit adaptive (auto) immune responses via killing of autologous myeloid and lymphoid cells. Investigating immunoregulatory NK-cell functions might generate exciting insights into the reciprocal regulation between NK-cell-mediated innate immunity and adaptive immune responses, improve our capacity to monitor these cells as surrogate markers for disease activity and treatment responses in autoimmune diseases, and, perhaps, provide new prospects for NK cell-directed therapies.

Statistics

Citations

56 citations in Web of Science®
64 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

63 downloads since deposited on 10 Jan 2010
5 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Experimental Immunology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2009
Deposited On:10 Jan 2010 13:09
Last Modified:03 Aug 2017 15:10
Publisher:North Shore Long Island Jewish Research Institute
ISSN:1076-1551
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.2119/molmed.2009.00035
PubMed ID:19603102

Download

Download PDF  'Regulatory NK-cell functions in inflammation and autoimmunity'.
Preview
Filetype: PDF
Size: 1MB
View at publisher