Header

UZH-Logo

Maintenance Infos

Evolution of feedback loops in oscillatory systems


Hafner, M; Koeppl, H; Wagner, A (2009). Evolution of feedback loops in oscillatory systems. In: Proceedings of the Third International Conference on Foundations of Systems Biology in Engineering (FOSBE 2009), Denver, CO, USA, 9 August 2009 - 12 August 2009, 157-160.

Abstract

Feedback loops are major components of biochemical system. Many systems show multiple such (positive or negative) feedback loops. Nevertheless, very few quantitative analyses that address the question how such multiple feedback loops evolved. Based on published models from the mitotic cycle in embryogenesis, we build a few case study models. Using a simple core architecture (transcription, phosphorylation and degradation), we define oscillatory models having either one positive feedback or one negative feedback, or both loops. With these models, we address the following questions about evolvability: could a system evolve from a simple model to a more complex one with a continuous transition in the parameter space? How do new feedback loops emerge without disrupting the proper function of the system? Our results show that progressive formation of a second feedback loop is possible without disturbing existing oscillatory behavior. For this process, the parameters of the system have to change during evolution to maintain predefined properties of oscillations like period and amplitude.

Abstract

Feedback loops are major components of biochemical system. Many systems show multiple such (positive or negative) feedback loops. Nevertheless, very few quantitative analyses that address the question how such multiple feedback loops evolved. Based on published models from the mitotic cycle in embryogenesis, we build a few case study models. Using a simple core architecture (transcription, phosphorylation and degradation), we define oscillatory models having either one positive feedback or one negative feedback, or both loops. With these models, we address the following questions about evolvability: could a system evolve from a simple model to a more complex one with a continuous transition in the parameter space? How do new feedback loops emerge without disrupting the proper function of the system? Our results show that progressive formation of a second feedback loop is possible without disturbing existing oscillatory behavior. For this process, the parameters of the system have to change during evolution to maintain predefined properties of oscillations like period and amplitude.

Statistics

Downloads

1 download since deposited on 22 Jan 2010
0 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Conference or Workshop Item (Paper), refereed, original work
Communities & Collections:04 Faculty of Medicine > Department of Biochemistry
07 Faculty of Science > Department of Biochemistry
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Event End Date:12 August 2009
Deposited On:22 Jan 2010 16:06
Last Modified:06 Dec 2017 23:09
Free access at:Related URL. An embargo period may apply.
Official URL:http://www.fosbe.org/
Related URLs:http://infoscience.epfl.ch/record/141979

Download