Header

UZH-Logo

Maintenance Infos

How does endothelial cell injury start? The role of endothelin in systemic sclerosis


Abraham, David; Distler, Oliver (2007). How does endothelial cell injury start? The role of endothelin in systemic sclerosis. Arthritis Research and Therapy, 9(Suppl 2):S2.

Abstract

A considerable amount of research time has been invested in studies aimed at elucidating pathogenic processes in systemic sclerosis (SSc). Despite this, major challenges for biomedical science remain, such as identification of the key factors that determine susceptibility to SSc, and elucidation of the precise nature of the initiating event that causes endothelial cell injury and ultimately brings about the biological cascade(s) that lead to the pathologic vascular changes. Involved factors are likely to include genetic perturbations, environmental cues, tissue injury, infection and hypoxia/oxidative stress. As important as determining the initiating events are the identification and characterization of key factors that are functionally important in driving vascular disease progression, because these factors are potential targets for therapeutic intervention. This article reviews the role of endothelin as an example of a pleiotropic mediator with effects on various aspects of SSc pathogenesis, such as inflammation, vasculopathy and tissue remodelling.

Abstract

A considerable amount of research time has been invested in studies aimed at elucidating pathogenic processes in systemic sclerosis (SSc). Despite this, major challenges for biomedical science remain, such as identification of the key factors that determine susceptibility to SSc, and elucidation of the precise nature of the initiating event that causes endothelial cell injury and ultimately brings about the biological cascade(s) that lead to the pathologic vascular changes. Involved factors are likely to include genetic perturbations, environmental cues, tissue injury, infection and hypoxia/oxidative stress. As important as determining the initiating events are the identification and characterization of key factors that are functionally important in driving vascular disease progression, because these factors are potential targets for therapeutic intervention. This article reviews the role of endothelin as an example of a pleiotropic mediator with effects on various aspects of SSc pathogenesis, such as inflammation, vasculopathy and tissue remodelling.

Statistics

Citations

68 citations in Web of Science®
81 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

57 downloads since deposited on 22 Aug 2008
13 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2007
Deposited On:22 Aug 2008 12:03
Last Modified:21 Nov 2017 13:27
Publisher:BioMed Central
ISSN:1478-6354
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1186/ar2186
PubMed ID:17767740

Download

Download PDF  'How does endothelial cell injury start? The role of endothelin in systemic sclerosis'.
Preview
Content: Published Version
Filetype: PDF
Size: 1MB
View at publisher