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Subcellular targeting strategies for drug design and delivery


Rajendran, L; Knölker, H J; Simons, K (2010). Subcellular targeting strategies for drug design and delivery. Nature Reviews. Drug Discovery, 9(1):29-42.

Abstract

Many drug targets are localized to particular subcellular compartments, yet current drug design strategies are focused on bioavailability and tissue targeting and rarely address drug delivery to specific intracellular compartments. Insights into how the cell traffics its constituents to these different cellular locations could improve drug design. In this Review, we explore the fundamentals of membrane trafficking and subcellular organization, as well as strategies used by pathogens to appropriate these mechanisms and the implications for drug design and delivery.

Abstract

Many drug targets are localized to particular subcellular compartments, yet current drug design strategies are focused on bioavailability and tissue targeting and rarely address drug delivery to specific intracellular compartments. Insights into how the cell traffics its constituents to these different cellular locations could improve drug design. In this Review, we explore the fundamentals of membrane trafficking and subcellular organization, as well as strategies used by pathogens to appropriate these mechanisms and the implications for drug design and delivery.

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310 citations in Web of Science®
303 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute for Regenerative Medicine (IREM)
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:January 2010
Deposited On:10 Feb 2010 15:48
Last Modified:04 Sep 2016 05:07
Publisher:Nature Publishing Group
ISSN:1474-1776
Publisher DOI:https://doi.org/10.1038/nrd2897
PubMed ID:20043027

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