Header

UZH-Logo

Maintenance Infos

Cellular immune responses and disease control in acute AIDS-associated Kaposi's sarcoma


Bihl, F; Berger, C; Chisholm, J V; Henry, L M; Bertisch, B; Trojan, A; Nadal, D; Speck, R F; Flepp, M; Brander, C; Mueller, N J (2009). Cellular immune responses and disease control in acute AIDS-associated Kaposi's sarcoma. AIDS, 23(14):1918-1922.

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) specific T cell responses and KSHV viremia were analyzed in seven HIV-infected patients with active Kaposi's sarcoma lesions who initiated highly active antiretroviral therapy, and were compared between patients with improved Kaposi's sarcoma and those with progressive Kaposi's sarcoma requiring further systemic chemotherapy. Patients with controlled Kaposi's sarcoma disease demonstrated undetectable Kaposi's sarcoma viremia together with KSHV-specific CD8 T cells secreting interferon-gamma and tumor necrosis factor-alpha, whereas progressors showed increasing viremia with weak or no T-cell responses. These data point toward a potential role of KSHV-specific immunity in the control of AIDS-associated Kaposi's sarcoma.

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) specific T cell responses and KSHV viremia were analyzed in seven HIV-infected patients with active Kaposi's sarcoma lesions who initiated highly active antiretroviral therapy, and were compared between patients with improved Kaposi's sarcoma and those with progressive Kaposi's sarcoma requiring further systemic chemotherapy. Patients with controlled Kaposi's sarcoma disease demonstrated undetectable Kaposi's sarcoma viremia together with KSHV-specific CD8 T cells secreting interferon-gamma and tumor necrosis factor-alpha, whereas progressors showed increasing viremia with weak or no T-cell responses. These data point toward a potential role of KSHV-specific immunity in the control of AIDS-associated Kaposi's sarcoma.

Statistics

Citations

13 citations in Web of Science®
15 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

292 downloads since deposited on 19 Jan 2010
64 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases
04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2009
Deposited On:19 Jan 2010 09:05
Last Modified:05 Apr 2016 13:45
Publisher:Lippincott Wiliams & Wilkins
ISSN:0269-9370
Additional Information:This is a non-final version of an article published in final form in AIDS, 23(14):1918-1922.
Publisher DOI:https://doi.org/10.1097/QAD.0b013e3283300a91
PubMed ID:19609199

Download

Preview Icon on Download
Preview
Content: Accepted Version
Filetype: PDF
Size: 1MB
View at publisher