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Efficacy of TachoSil a fibrin-based haemostat in different fields of surgery - a systematic review


Rickenbacher, A; Breitenstein, S; Lesurtel, M; Frilling, A (2009). Efficacy of TachoSil a fibrin-based haemostat in different fields of surgery - a systematic review. Expert Opinion on Biological Therapy, 9(7):897-907.

Abstract

BACKGROUND: Proper haemostasis is an important prerequisite for a successful outcome in all operative fields. TachoSil is used in many surgical specialties, especially for diffuse bleeding. However, TachoSil is not only used for haemostasis but also for closure of other anatomical structures. OBJECTIVE: To review the literature concerning the efficacy of TachoSil, a topical fibrin-based haemostat. METHODS: PubMed was searched for data on TachoSil and TachoComb from clinical trials and basic research. RESULTS/CONCLUSION: TachoSil is used in many surgical specialties and has proven to be a valuable tool for several indications. It also seems to be cost effective. Solid data from randomized controlled trials are available for liver surgery, thoracic surgery and urology where a positive value is clearly documented.

Abstract

BACKGROUND: Proper haemostasis is an important prerequisite for a successful outcome in all operative fields. TachoSil is used in many surgical specialties, especially for diffuse bleeding. However, TachoSil is not only used for haemostasis but also for closure of other anatomical structures. OBJECTIVE: To review the literature concerning the efficacy of TachoSil, a topical fibrin-based haemostat. METHODS: PubMed was searched for data on TachoSil and TachoComb from clinical trials and basic research. RESULTS/CONCLUSION: TachoSil is used in many surgical specialties and has proven to be a valuable tool for several indications. It also seems to be cost effective. Solid data from randomized controlled trials are available for liver surgery, thoracic surgery and urology where a positive value is clearly documented.

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50 citations in Web of Science®
50 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Visceral and Transplantation Surgery
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2009
Deposited On:30 Jan 2010 18:38
Last Modified:05 Apr 2016 13:48
Publisher:Informa Healthcare
ISSN:1471-2598
Publisher DOI:https://doi.org/10.1517/14712590903029172
PubMed ID:19527109

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